Primary cardiomyocyte work-loop assay to predict inotropic drug effects of checkpoint kinase inhibitors

2020 ◽  
Vol 105 ◽  
pp. 106758
Author(s):  
Mayel Gharanei ◽  
Jeremy Billson ◽  
Oana Blair ◽  
Josh Hurst ◽  
Adam Linekar ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Drug Effects ◽  
Checkpoint Kinase ◽  
Inotropic Drug ◽  
Work Loop

Work-loop assay to predict inotropic drug effects of checkpoint kinase inhibitors

2016 ◽  
Vol 81 ◽  
pp. 362
Author(s):  
Mayel Gharanei ◽  
Rob Wallis ◽  
Maryam Babba ◽  
Andre Varcianna ◽  
Helen Maddock
Keyword(s):  
Kinase Inhibitors ◽  
Drug Effects ◽  
Checkpoint Kinase ◽  
Inotropic Drug ◽  
Work Loop

Abstract 4907: Elucidating the role of retroactive signaling and kinase inhibitors on off-target drug effects

2011 ◽  
Author(s):  
Michelle L. Wynn ◽  
Alejandra C. Ventura ◽  
Hector Garcia ◽  
Jacques-A. Sepulchre ◽  
Sofia D. Merajver
Keyword(s):  
Kinase Inhibitors ◽  
Drug Effects ◽  
Target Drug

The Challenge of Combining Chemo- and Radiotherapy with Checkpoint Kinase Inhibitors

2020 ◽  
Author(s):  
Linda van Bijsterveldt ◽  
Samuel C. Durley ◽  
Tim S. Maughan ◽  
Timothy C. Humphrey
Keyword(s):  
Kinase Inhibitors ◽  
Checkpoint Kinase

scholarly journals G2 Checkpoint Kinase Inhibitors Exert Their Radiosensitizing Effects Prior to the G2/M Transition

Cell Cycle ◽  
2007 ◽  
Vol 6 (5) ◽  
pp. 572-575 ◽  
Author(s):  
Christopher M. Sturgeon ◽  
Michel Roberge
Keyword(s):  
Kinase Inhibitors ◽  
Checkpoint Kinase ◽  
G2 Checkpoint

Abstract 129: RAD17 loss of function is synthetically lethal with the checkpoint kinase inhibitors AZD7762 or MK-1775

2015 ◽  
Author(s):  
John Paul Shen ◽  
Rohith Srivas ◽  
Ana Bojorquez-Gomez ◽  
Katherine Licon ◽  
Vignesh Sivaganesh ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Loss Of Function ◽  
Checkpoint Kinase ◽  
Synthetically Lethal

Checkpoint Kinase Inhibitors:  SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles

2005 ◽  
Vol 48 (6) ◽  
pp. 1873-1885 ◽  
Author(s):  
Kristen L. Arienti ◽  
Anders Brunmark ◽  
Frank U. Axe ◽  
Kelly McClure ◽  
Alice Lee ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Checkpoint Kinase ◽  
Radioprotective Properties
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