Evaluating the combined impact of temperature and application of interfacial dilatational stresses on surface-mediated protein particle formation in monoclonal antibody formulations

2021 ◽  
Author(s):  
Valerie Pringle ◽  
Kimberly Merritt ◽  
Coleman Vaclaw ◽  
Neal Whitaker ◽  
David B. Volkin ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Particle Formation ◽  
Protein Particle ◽  
Combined Impact

Gelation of a Monoclonal Antibody at the Silicone Oil–Water Interface and Subsequent Rupture of the Interfacial Gel Results in Aggregation and Particle Formation

2015 ◽  
Vol 104 (4) ◽  
pp. 1282-1290 ◽  
Author(s):  
Shyam B. Mehta ◽  
Rachael Lewus ◽  
Jared S. Bee ◽  
Theodore W. Randolph ◽  
John F. Carpenter
Keyword(s):  
Monoclonal Antibody ◽  
Silicone Oil ◽  
Particle Formation ◽  
Water Interface ◽  
Oil Water

Characterization of Subvisible Particle Formation During the Filling Pump Operation of a Monoclonal Antibody Solution

2011 ◽  
Vol 100 (10) ◽  
pp. 4198-4204 ◽  
Author(s):  
Arpan Nayak ◽  
James Colandene ◽  
Victor Bradford ◽  
Melissa Perkins
Keyword(s):  
Monoclonal Antibody ◽  
Particle Formation ◽  
Pump Operation ◽  
Antibody Solution

Trace levels of the CHO host cell protease cathepsin D caused particle formation in a monoclonal antibody product

2015 ◽  
Vol 31 (5) ◽  
pp. 1360-1369 ◽  
Author(s):  
Jared S. Bee ◽  
Liu Tie ◽  
Douglas Johnson ◽  
Mariana N. Dimitrova ◽  
Kristin C. Jusino ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Host Cell ◽  
Cathepsin D ◽  
Particle Formation ◽  
Monoclonal Antibody Product

scholarly journals Control of Protein Particle Formation During Ultrafiltration/Diafiltration Through Interfacial Protection

2014 ◽  
Vol 103 (3) ◽  
pp. 862-869 ◽  
Author(s):  
Daniel J. Callahan ◽  
Bradford Stanley ◽  
Yuling Li
Keyword(s):  
Particle Formation ◽  
Protein Particle

Interfacial dilatational deformation accelerates particle formation in monoclonal antibody solutions

Soft Matter ◽  
2016 ◽  
Vol 12 (14) ◽  
pp. 3293-3302 ◽  
Author(s):  
Gigi L. Lin ◽  
Jai A. Pathak ◽  
Dong Hyun Kim ◽  
Marcia Carlson ◽  
Valeria Riguero ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Particle Formation
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