scholarly journals Surface biotinylation of primary neurons to monitor changes in AMPA receptor surface expression in response to kainate receptor stimulation

2021 ◽  
Vol 2 (4) ◽  
pp. 100992
Author(s):  
Jithin D. Nair ◽  
Jeremy M. Henley ◽  
Kevin A. Wilkinson
Keyword(s):  
Ampa Receptor ◽  
Surface Expression ◽  
Kainate Receptor ◽  
Primary Neurons ◽  
Receptor Stimulation ◽  
Receptor Surface Expression

scholarly journals Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

iScience ◽  
2021 ◽  
pp. 103029
Author(s):  
Jithin D. Nair ◽  
Ellen Braksator ◽  
Busra P. Yucel ◽  
Alexandra Fletcher-Jones ◽  
Richard Seager ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Surface Expression ◽  
Receptor Activation ◽  
Kainate Receptor ◽  
Receptor Surface Expression

scholarly journals Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

2020 ◽  
Author(s):  
Jithin D. Nair ◽  
Ellen Braksator ◽  
Busra P Yucel ◽  
Richard Seager ◽  
Jack R. Mellor ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Ampa Receptors ◽  
Hippocampal Neurons ◽  
Hippocampal Slices ◽  
Surface Expression ◽  
Receptor Activation ◽  
Kainate Receptors ◽  
Receptor Surface Expression ◽  
Acute Hippocampal Slices

AbstractHere we report that sustained activation of GluK2 subunit-containing kainate receptors leads to AMPA receptor endocytosis and a novel form of long-term depression (KAR-LTDAMPAR) in hippocampal neurons. The KAR-evoked loss of surface AMPA receptors requires KAR channel activity and is occluded by the blockade of PKC or PKA. Moreover, in acute hippocampal slices, kainate invoked LTD of AMPA EPSCs. These data, together with our previously reported KAR-LTPAMPAR, demonstrate that KARs bidirectionally regulate synaptic AMPARs and synaptic plasticity.

REGULATION OF AMPA RECEPTOR SURFACE EXPRESSION BY A NSF-DEPENDENT MECHANISM IN HIPPOCAMPAL NEURONS IN CULTURE

1999 ◽  
Vol 27 (3) ◽  
pp. A117-A117
Author(s):  
J. Noel ◽  
G. Scott Ralph ◽  
L. Pickard ◽  
E. Molnar ◽  
J. B. Uney ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Surface Expression ◽  
Receptor Surface Expression ◽  
Dependent Mechanism

scholarly journals Bidirectional Regulation of Kainate Receptor Surface Expression in Hippocampal Neurons

2008 ◽  
Vol 283 (52) ◽  
pp. 36435-36440 ◽  
Author(s):  
Stéphane Martin ◽  
Tristan Bouschet ◽  
Emma L. Jenkins ◽  
Atsushi Nishimune ◽  
Jeremy M. Henley
Keyword(s):  
Hippocampal Neurons ◽  
Surface Expression ◽  
Kainate Receptor ◽  
Bidirectional Regulation ◽  
Receptor Surface Expression

scholarly journals PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression

2011 ◽  
Vol 30 (20) ◽  
pp. 4274-4286 ◽  
Author(s):  
Chi Bun Chan ◽  
Yongjun Chen ◽  
Xia Liu ◽  
Xiaoling Tang ◽  
Chi Wai Lee ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Kinase Activity ◽  
Surface Expression ◽  
Pi3 Kinase ◽  
Receptor Surface Expression
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