The presynaptic active zone: A dynamic scaffold that regulates synaptic efficacy

2015 ◽  
Vol 335 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Katrin Michel ◽  
Johannes Alexander Müller ◽  
Ana-Maria Oprişoreanu ◽  
Susanne Schoch
Keyword(s):  
Active Zone ◽  
Synaptic Efficacy ◽  
Presynaptic Active Zone

Amyloid Precursor Protein Knockout Diminishes Synaptic Vesicle Proteins at the Presynaptic Active Zone in Mouse Brain

2014 ◽  
Vol 11 (10) ◽  
pp. 971-980 ◽  
Author(s):  
Melanie Laßek ◽  
Jens Weingarten ◽  
Amparo Acker-Palmer ◽  
Sandra Bajjalieh ◽  
Ulrike Muller ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Synaptic Vesicle ◽  
Mouse Brain ◽  
Active Zone ◽  
Precursor Protein ◽  
Presynaptic Active Zone ◽  
Vesicle Proteins

scholarly journals Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression

Cell Reports ◽  
2016 ◽  
Vol 14 (6) ◽  
pp. 1369-1381 ◽  
Author(s):  
Rajit Rajappa ◽  
Anne Gauthier-Kemper ◽  
Daniel Böning ◽  
Jana Hüve ◽  
Jürgen Klingauf
Keyword(s):  
Active Zone ◽  
Short Term ◽  
Presynaptic Active Zone

scholarly journals Assembling the Presynaptic Active Zone

Neuron ◽  
2001 ◽  
Vol 29 (1) ◽  
pp. 131-143 ◽  
Author(s):  
Rong Grace Zhai ◽  
Hagit Vardinon-Friedman ◽  
Claudia Cases-Langhoff ◽  
Birgit Becker ◽  
Eckart D. Gundelfinger ◽  
...  
Keyword(s):  
Active Zone ◽  
Presynaptic Active Zone

scholarly journals Assembly of the presynaptic active zone

2020 ◽  
Vol 63 ◽  
pp. 95-103 ◽  
Author(s):  
Javier Emperador-Melero ◽  
Pascal S Kaeser
Keyword(s):  
Active Zone ◽  
Presynaptic Active Zone

scholarly journals Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone

2015 ◽  
Vol 11 (9) ◽  
pp. e1004407 ◽  
Author(s):  
Alexander Ullrich ◽  
Mathias A. Böhme ◽  
Johannes Schöneberg ◽  
Harald Depner ◽  
Stephan J. Sigrist ◽  
...  
Keyword(s):  
Active Zone ◽  
Syntaxin 1A ◽  
Presynaptic Active Zone

scholarly journals The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels

2009 ◽  
Vol 108 (3) ◽  
pp. 662-675 ◽  
Author(s):  
Marco Morciano ◽  
Tobias Beckhaus ◽  
Michael Karas ◽  
Herbert Zimmermann ◽  
Walter Volknandt
Keyword(s):  
Adhesion Molecules ◽  
Active Zone ◽  
Synaptic Vesicles ◽  
Presynaptic Active Zone

scholarly journals APP—A Novel Player within the Presynaptic Active Zone Proteome

2017 ◽  
Vol 10 ◽  
Author(s):  
Jens Weingarten ◽  
Melanie Weingarten ◽  
Martin Wegner ◽  
Walter Volknandt
Keyword(s):  
Active Zone ◽  
Presynaptic Active Zone

scholarly journals S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development

2011 ◽  
Vol 194 (6) ◽  
pp. 921-935 ◽  
Author(s):  
Ling Cheng ◽  
Cody Locke ◽  
Graeme W. Davis
Keyword(s):  
Active Zone ◽  
Neurotransmitter Release ◽  
Synaptic Function ◽  
Growth Factor Signaling ◽  
Neuron Type ◽  
S6 Kinase ◽  
Neuronal Dendrites ◽  
Presynaptic Boutons ◽  
Presynaptic Active Zone ◽  
Presynaptic Protein

The dimensions of neuronal dendrites, axons, and synaptic terminals are reproducibly specified for each neuron type, yet it remains unknown how these structures acquire their precise dimensions of length and diameter. Similarly, it remains unknown how active zone number and synaptic strength are specified relative the precise dimensions of presynaptic boutons. In this paper, we demonstrate that S6 kinase (S6K) localizes to the presynaptic active zone. Specifically, S6K colocalizes with the presynaptic protein Bruchpilot (Brp) and requires Brp for active zone localization. We then provide evidence that S6K functions downstream of presynaptic PDK1 to control synaptic bouton size, active zone number, and synaptic function without influencing presynaptic bouton number. We further demonstrate that PDK1 is also a presynaptic protein, though it is distributed more broadly. We present a model in which synaptic S6K responds to local extracellular nutrient and growth factor signaling at the synapse to modulate developmental size specification, including cell size, bouton size, active zone number, and neurotransmitter release.

Sign in / Sign up

Export Citation Format

Share Document