Epidermal growth factor inhibits both cholecystokinin octapeptide-induced inositol 1,4,5-trisphosphate production and [Ca2+]i increase in rat pancreatic acinar cells

1991 ◽  
Vol 180 (2) ◽  
pp. 900-906 ◽  
Author(s):  
André Pröfrock ◽  
Albrecht Piiper ◽  
Luise Eckhardt ◽  
Irene Schulz
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Cholecystokinin Octapeptide ◽  
Inositol 1,4,5 Trisphosphate ◽  
Epidermal Growth

Epidermal Growth Factor Receptor Signaling in Rat Pancreatic Acinar Cells

Pancreas ◽  
1995 ◽  
Vol 10 (3) ◽  
pp. 274-280 ◽  
Author(s):  
Danuta Stryjek-Kaminska ◽  
Albrecht Piiper ◽  
Jürgen Stein ◽  
Wolfgang F. Caspary ◽  
Stefan Zeuzem
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Receptor Signaling ◽  
Epidermal Growth ◽  
Growth Factor Receptor Signaling

Dietary Modulation of Epidermal Growth Factor Action in Cultured Pancreatic Acinar Cells of the Rat

1986 ◽  
Vol 116 (7) ◽  
pp. 1306-1315 ◽  
Author(s):  
Patsy M. Brannon ◽  
Alison S. Demarest ◽  
Janet E. Sabb ◽  
Murray Korc
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Dietary Modulation ◽  
Epidermal Growth

Stimulation of pancreatic acinar cell growth by CCK, epidermal growth factor, and insulin in vitro

1986 ◽  
Vol 251 (4) ◽  
pp. G487-G494 ◽  
Author(s):  
C. D. Logsdon
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Dna Synthesis ◽  
Acinar Cell ◽  
Acinar Cells ◽  
Pancreatic Acinar Cell ◽  
Pancreatic Acinar Cells ◽  
Intracellular Camp ◽  
Ionophore A23187 ◽  
Epidermal Growth

Effects of regulatory molecules on growth of mouse pancreatic acinar cells in culture were examined. The cholecystokinin (CCK) analogue caerulein and cholecystokinin octapeptide (CCK-8) each led to threefold increases in incorporation of [3H]thymidine into DNA. Gastrin, which interacts weakly with the CCK receptor, stimulated DNA synthesis, but only at much higher concentrations. In contrast, other secretagogues that utilize Ca2+ as an intracellular messenger, including carbachol, bombesin, substance P, and the ionophore A23187, did not induce trophic responses. Factors that affect intracellular cAMP concentration, such as secretin, somatostatin, VIP, DBcAMP, and forskolin, did not increase DNA synthesis in cultured pancreatic cells. Insulin and epidermal growth factor induced two- and threefold increases in [3H] thymidine incorporation into DNA, respectively. The effects of insulin were mediated via insulin-like growth factor I receptors. Steroid hormones had little effect on pancreatic acinar cell DNA synthesis. The stimulatory effects of CCK, insulin, and EGF were additive. The combination of caerulein, EGF, and insulin in a hormonally defined medium led to a tenfold increase in the incorporation of [3H]thymidine into DNA. These data indicate that CCK, EGF, and insulin directly increase DNA synthesis in pancreatic acinar cells.

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