Persistence of effects of nitric oxide synthase inhibitors: Comparisons on blood flow and plasma exudation in guinea pig skin

1997 ◽  
Vol 330 (2-3) ◽  
pp. 241-246 ◽  
Author(s):  
Andrea C Perez ◽  
Aamir M Khawaja ◽  
Clive P Page ◽  
William Paul
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Nitric Oxide Synthase ◽  
Guinea Pig ◽  
Nitric Oxide Synthase Inhibitors ◽  
Pig Skin ◽  
Plasma Exudation ◽  
Oxide Synthase

scholarly journals Modulation of guinea-pig cardiac L-type calcium current by nitric oxide synthase inhibitors

1998 ◽  
Vol 506 (3) ◽  
pp. 639-651 ◽  
Author(s):  
Maria Pia Gallo ◽  
Dario Ghigo ◽  
Amalia Bosia ◽  
Giuseppe Alloatti ◽  
Costanzo Costamagna ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Guinea Pig ◽  
Calcium Current ◽  
Nitric Oxide Synthase Inhibitors ◽  
Oxide Synthase

Effects of Nitric Oxide Synthase Inhibitors on Cerebral Blood Flow and Autoregulation in Rats

1992 ◽  
Vol 77 (Supplement) ◽  
pp. A689 ◽  
Author(s):  
D S DeWitt ◽  
D S Prough ◽  
D M Colonna ◽  
D D Deal ◽  
S M Vines
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Nitric Oxide Synthase ◽  
Nitric Oxide Synthase Inhibitors ◽  
Oxide Synthase

Nitric oxide synthase inhibitors do not alter functional hyperemia in canine skeletal muscle

1994 ◽  
Vol 72 (9) ◽  
pp. 1035-1041 ◽  
Author(s):  
J. K. Barclay ◽  
N. E. Woodley
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Nitric Oxide Synthase ◽  
Vascular Reactivity ◽  
Functional Hyperemia ◽  
Nitric Oxide Synthase Inhibitor ◽  
Nitric Oxide Synthase Inhibitors ◽  
Steady Level ◽  
Oxide Synthase

To test the hypothesis that endothelium-derived products contribute to functional hyperemia in skeletal muscle, we infused nitric oxide synthase inhibitors, either 200 μM Nω-nitro-L-arginine (NNA) (N = 4) or 1 mM Nγ-monomethyl-L-arginine (NMMA) (N = 4), before and during 6 min of 4 Hz stimulation of canine gastrocnemius in situ. We infused saline (N = 4) as a control. NNA significantly decreased steady-level resting flow by 3.8 ± 0.4 mL∙kg−1∙s−1. The increase in flow from rest to 5 min of stimulation was not changed by the nitric oxide synthase inhibitors. We also stimulated muscles for 60 min either with saline infusion (N = 4) or with the infusion of saline during the first 15 min and NNA for the remaining 45 min (N = 4). There was no difference in the flow during contractions. To clarify the effect of these inhibitors on canine vessels, we challenged rings of canine femoral artery with and without endothelium with acetylcholine and bradykinin (both 1 μM) before and after the addition of NNA and NMMA (both 10 μM). The nitric oxide synthase inhibitors decreased the relaxation accompanying acetylcholine. Both inhibitors caused only endothelium-intact rings to contract. Thus, the presence of a nitric oxide synthase inhibitor identified an endothelium-dependent contribution to the regulation of blood flow to skeletal muscle at rest but had no effect on functional hyperemia.Key words: vascular reactivity, functional hyperemia, steady-level blood flow, endothelium-derived factors, Nω-nitro-L-arginine, Nγ-monomethyl-L-arginine.

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