Cannabinoid CB1 receptor distribution and function in neurally mediated chloride secretion in the guinea pig ileum

2003 ◽  
Vol 124 (4) ◽  
pp. A342 ◽  
Author(s):  
Wallace K. Macnaughton ◽  
Kelly Cushing ◽  
Marja D. Van Sickle ◽  
Catherine M. Keenan ◽  
Kenneth Mackie ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Chloride Secretion ◽  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Guinea Pig Ileum ◽  
And Function ◽  
Receptor Distribution

W1363 Real Time Detection and Function of Melatonin Release from the Mucosa of Guinea Pig Ileum

2008 ◽  
Vol 134 (4) ◽  
pp. A-688 ◽  
Author(s):  
Bhavik A. Patel ◽  
Xiaochun Bian ◽  
James Galligan ◽  
Greg M. Swain
Keyword(s):  
Guinea Pig ◽  
Real Time ◽  
Guinea Pig Ileum ◽  
Real Time Detection ◽  
And Function

Localisation of cannabinoid CB1 receptor immunoreactivity in the guinea pig and rat myenteric plexus

2002 ◽  
Vol 448 (4) ◽  
pp. 410-422 ◽  
Author(s):  
Angela A. Coutts ◽  
Andrew J. Irving ◽  
Ken Mackie ◽  
Roger G. Pertwee ◽  
Sharon Anavi-Goffer
Keyword(s):  
Guinea Pig ◽  
Myenteric Plexus ◽  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor

scholarly journals Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries

1998 ◽  
Vol 123 (5) ◽  
pp. 968-974 ◽  
Author(s):  
T Chataigneau ◽  
M Félétou ◽  
C Thollon ◽  
N Villeneuve ◽  
J- P. Vilaine ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Coronary Arteries ◽  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor

scholarly journals Bioorganic studies on the venom from duckbill platypus

2012 ◽  
Vol 84 (6) ◽  
pp. 1317-1328 ◽  
Author(s):  
Masaki Kita
Keyword(s):  
Molecular Weight ◽  
Guinea Pig ◽  
Structure And Function ◽  
Low Molecular Weight ◽  
Tissue Kallikrein ◽  
Guinea Pig Ileum ◽  
Porcine Pancreas ◽  
Human Neuroblastoma ◽  
Ornithorhynchus Anatinus ◽  
And Function

Venomous mammals are rare, and only a few species in the orders Insectivora and Monotremata produce toxic venom. Among them, the duckbill platypus (Ornithorhynchus anatinus) is one of the two venomous Australian mammals. The adult male platypus carries a spur on each hind leg, which it uses to inject competitors with poison. However, the structure and function of the poison’s active compounds are still imcompletely characterized. We found that crude platypus venom produced potent Ca2+influx in human neuroblastoma IMR-32 cells. Guided by this assay, we identified 11 unique peptides, including peptide H–His–Asp–His–Pro–Asn–Pro–Arg–OH, which coincided with the N-terminal domain residues ofOrnithorhynchusvenom C-type natriuretic peptide (OvCNP). This heptapeptide induced a significant increase in [Ca2+]iin IMR-32 cells at 75 μM; had relatively specific affinities for glutamate, histamine, and GABAAreceptors; and facilitated neurogenic twitching in guinea pig ileum specimens at 30 μM. We also established that its proteinous venom fraction strongly hydrolyzed Pro–Phe–Arg–MCA and cleaved a human low-molecular-weight kininogen (LK), similar to porcine pancreas kallikrein. These results strongly indicated that platypus venom contains tissue kallikrein-like protease(s), and its proteolytic activity might synergistically contribute to toxicity through the specific cleavage of other venom constituents.

257 Activation of the Glucagon-Like Peptide-2 Receptor Inhibits Neurally-Evoked Mucosal Chloride Secretion in the Guinea Pig Ileum In Vitro

2009 ◽  
Vol 136 (5) ◽  
pp. A-50
Author(s):  
Sara Baldassano ◽  
Sumei Liu ◽  
Mei-Hua Qu ◽  
Wei Ren ◽  
Xiyu Wang ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Chloride Secretion ◽  
Guinea Pig Ileum ◽  
Glucagon Like Peptide
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