Su1655 – Administration of Neostigmine and Glycopyrrolate by Transdermal Iontophoresis Decreases Time of Bowel Care and Increases Completeness of Bowel Evacuation in Persons with Chronic Constipation Secondary to Spinal Cord Injury

2019 ◽  
Vol 156 (6) ◽  
pp. S-600
Author(s):  
Anton Sabiev ◽  
Shahzad Shallwani ◽  
Yash Shah ◽  
William A. Bauman ◽  
Tradd Cummings ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chronic Constipation ◽  
Cord Injury ◽  
Transdermal Iontophoresis ◽  
Bowel Evacuation

scholarly journals The Addition of Transdermal Delivery of Neostigmine and Glycopyrrolate by Iontophoresis to Thrice Weekly Bowel Care in Persons with Spinal Cord Injury: A Pilot Study

2021 ◽  
Vol 10 (5) ◽  
pp. 1135
Author(s):  
William A. Bauman ◽  
Anton Sabiev ◽  
Shahzad Shallwani ◽  
Ann M. Spungen ◽  
Christopher M. Cirnigliaro ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Standard Of Care ◽  
Bowel Function ◽  
Abdominal Radiograph ◽  
Drug Intervention ◽  
Cord Injury ◽  
Abdominal Radiographs ◽  
Dual Drug ◽  
Bowel Evacuation

Persons with spinal cord injury (SCI) have neurogenic bowel disorders characterized by difficulty with evacuation (DWE), fecal incontinence, and discoordination of defecation. Six medically stable in-patients with SCI with a mean age of 57 ± 10 years (range: 39–66 years) and time since injury of 18 ± 17 years (range: 3–47 years) were investigated. Standard of care (SOC) for bowel care was followed by two weeks of SOC plus neostigmine (0.07 mg/kg) and glycopyrrolate (0.014 mg/kg) administered transcutaneously by iontophoresis thrice weekly for two weeks while patients continued to receive SOC. The primary endpoint was time to bowel evacuation. Body weights and abdominal radiographs were obtained. Ten questions related to bowel function and the Treatment Satisfaction Questionnaire for Medication were acquired after each arm. Bowel evacuation time decreased after the dual drug intervention arm (106.9 ± 68.4 vs. 40.8 ± 19.6 min; p < 0.0001). Body weight decreased (2.78 ± 0.98 kg; p < 0.0001), a finding confirmed on abdominal radiograph. Both questionnaires demonstrated improvement after the dual drug intervention arm. No major adverse events occurred. The addition of neostigmine and glycopyrrolate by transcutaneous administration to SOC for bowel care in persons with SCI and DWE resulted in the safe, effective, and predictable bowel evacuation with subjective improvement in bowel care.

Su1587 Neostigmine and Glycopyrrolate Delivered Transdermally by Iontophoresis Safely Stimulates Bowel Evacuation in Persons With Spinal Cord Injury: A Novel Approach to Bowel Care

2016 ◽  
Vol 150 (4) ◽  
pp. S535
Author(s):  
Mark A. Korsten ◽  
Miroslav Radulovic ◽  
Brian Lyons ◽  
Ravi Vinnakota ◽  
Kamaldeep Singh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Novel Approach ◽  
Cord Injury ◽  
Bowel Evacuation

scholarly journals Autonomic dysreflexia during bowel evacuation procedures and bladder filling in subjects with spinal cord injury

Spinal Cord ◽  
2014 ◽  
Vol 52 (6) ◽  
pp. 494-498 ◽  
Author(s):  
P M Faaborg ◽  
P Christensen ◽  
A Krassioukov ◽  
S Laurberg ◽  
E Frandsen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Autonomic Dysreflexia ◽  
Bladder Filling ◽  
Cord Injury ◽  
Bowel Evacuation

Infusion of Neostigmine-Glycopyrrolate for Bowel Evacuation in Persons with Spinal Cord Injury

2005 ◽  
Vol 100 (7) ◽  
pp. 1560-1565 ◽  
Author(s):  
Mark A. Korsten ◽  
Alan S. Rosman ◽  
Anthony Ng ◽  
Erdal Cavusoglu ◽  
Ann M. Spungen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
Bowel Evacuation

Intramuscular Neostigmine and Glycopyrrolate Safely Accelerated Bowel Evacuation in Patients with Spinal Cord Injury and Defecatory Disorders

2008 ◽  
Vol 53 (10) ◽  
pp. 2710-2713 ◽  
Author(s):  
Alan S. Rosman ◽  
Geeta Chaparala ◽  
Amit Monga ◽  
Ann M. Spungen ◽  
William A. Bauman ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
Bowel Evacuation

scholarly journals Colonic stasis and chronic constipation: Demystifying proposed risk factors for colon polyp formation in a spinal cord injury veteran population

2017 ◽  
Vol 41 (3) ◽  
pp. 292-297
Author(s):  
Jason Colizzo ◽  
Jonathan Keshishian ◽  
Ambuj Kumar ◽  
Gitanjali Vidyarthi ◽  
Donald Amodeo
Keyword(s):  
Risk Factors ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chronic Constipation ◽  
Colon Polyp ◽  
Polyp Formation ◽  
Cord Injury

scholarly journals S501 Understanding the Pathophysiology of Chronic Constipation in Patients With Spinal Cord Injury

2021 ◽  
Vol 116 (1) ◽  
pp. S224-S224
Author(s):  
Gianna M. Rodriguez ◽  
Jason Baker ◽  
Martin Forchheimer ◽  
Richard Saad ◽  
Denise G. Tate ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chronic Constipation ◽  
Cord Injury
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