scholarly journals Studies on the Nuclear and Nucleolar Ribonucleic Acid of Regenerating Rat Liver

1965 ◽  
Vol 240 (10) ◽  
pp. 3960-3966
Author(s):  
Masami Muramatsu ◽  
Harris Busch
Keyword(s):  
Rat Liver ◽  
Ribonucleic Acid ◽  
Regenerating Rat Liver

RIBONUCLEASE ACTIVITY IN REGENERATING RAT LIVER

1967 ◽  
Vol 45 (7) ◽  
pp. 1021-1026 ◽  
Author(s):  
D. J. S. Arora ◽  
G. de Lamirande
Keyword(s):  
Enzymatic Activity ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Ribonucleic Acid ◽  
Ribonuclease Activity ◽  
Regenerating Liver ◽  
Early Stages ◽  
Regenerating Rat Liver ◽  
Ribonucleoprotein Particles

Ribonucleoprotein particles were isolated from sham-hepatectomized and partially hepatectomized animals. The levels of ribonucleic acid and of proteins, as well as the ribosomal ribonuclease activity, have been studied in regenerating liver at periods of 4, 8, 16, 36, and 72 hours after partial hepatectomy. The results showed that the amount of ribosomes in regenerating rat liver was not affected as compared with the level observed in sham-operated rats. However, a decrease of ribonuclease activity was noticed in the early stages of liver regeneration. The ribonuclease activity was practically negligible at 16 and 36 hours. Less than 50% of the enzymatic activity was regained at the 72-hour period after partial hepatectomy.Results show that the ribosomes from regenerating liver are more stable and the stabilizing factor seems to be the absence of ribonuclease.

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