scholarly journals Identification of enhancers in the 5'-flanking region of the rabbit surfactant protein A (SP-A) gene and characterization of their binding proteins.

1993 ◽  
Vol 268 (26) ◽  
pp. 19697-19709
Author(s):  
E Gao ◽  
J.L. Alcorn ◽  
C.R. Mendelson
Keyword(s):  
Binding Proteins ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Flanking Region

Disparate effects of two phosphatidylcholine binding proteins, C-reactive protein and surfactant protein A, on pulmonary surfactant structure and function

2004 ◽  
Vol 287 (6) ◽  
pp. L1145-L1153 ◽  
Author(s):  
Kaushik Nag ◽  
Karina Rodriguez-Capote ◽  
Amiya Kumar Panda ◽  
Laura Frederick ◽  
Stephen A. Hearn ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Amorphous Material ◽  
Protein A ◽  
Surfactant Protein ◽  
Water Soluble ◽  
Surfactant Protein A ◽  
Surface Films ◽  
Inhibitory Effects ◽  
C Reactive Protein ◽  
Reactive Protein

C-reactive protein (CRP) and surfactant protein A (SP-A) are phosphatidylcholine (PC) binding proteins that function in the innate host defense system. We examined the effects of CRP and SP-A on the surface activity of bovine lipid extract surfactant (BLES), a clinically applied modified natural surfactant. CRP inhibited BLES adsorption to form a surface-active film and the film's ability to lower surface tension (γ) to low values near 0 mN/m during surface area reduction. The inhibitory effects of CRP were reversed by phosphorylcholine, a water-soluble CRP ligand. SP-A enhanced BLES adsorption and its ability to lower γ to low values. Small amounts of SP-A blocked the inhibitory effects of CRP. Electron microscopy showed CRP has little effect on the lipid structure of BLES. SP-A altered BLES multilamellar vesicular structure by generating large, loose bilayer structures that were separated by a fuzzy amorphous material, likely SP-A. These studies indicate that although SP-A and CRP both bind PC, there is a difference in the manner in which they interact with surface films.

Characterization of the rat pulmonary surfactant protein A promoter

1992 ◽  
Vol 206 (3) ◽  
pp. 613-623 ◽  
Author(s):  
Thierry LACAZE-MASMONTEIL ◽  
Caroline FRASLON ◽  
Jacques BOURBON ◽  
Michel RAYMONDJEAN ◽  
Axel KAHN
Keyword(s):  
Pulmonary Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Pulmonary Surfactant Protein

scholarly journals Surfactant protein A-binding proteins. Characterization and structures.

1993 ◽  
Vol 268 (25) ◽  
pp. 18679-18684 ◽  
Author(s):  
D.S. Strayer ◽  
S. Yang ◽  
H.H. Jerng
Keyword(s):  
Binding Proteins ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A

Molecular Biological Characterization of Equine Surfactant Protein A

2002 ◽  
Vol 49 (10) ◽  
pp. 497-498 ◽  
Author(s):  
R. Hospes ◽  
B. I. L. Hospes ◽  
I. Reiss ◽  
H. Bostedt ◽  
L. Gortner
Keyword(s):  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Biological Characterization

scholarly journals Characterization of the Ca2+-dependent binding of annexin IV to surfactant protein A

1999 ◽  
Vol 341 (1) ◽  
pp. 203 ◽  
Author(s):  
Hitoshi SOHMA ◽  
Carl E. CREUTZ ◽  
Masaki SAITOH ◽  
Hitomi SANO ◽  
Yoshio KUROKI ◽  
...  
Keyword(s):  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Annexin Iv

Expression and characterization of rat surfactant protein A synthesized in Chinese hamster ovary cells

1990 ◽  
Vol 1087 (2) ◽  
pp. 190-198 ◽  
Author(s):  
Francis X. McCormack ◽  
James H. Fisher ◽  
Akira Suwabe ◽  
David L. Smith ◽  
John M. Shannon ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Protein A ◽  
Chinese Hamster ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Ovary Cells
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