Adsorption chromatographic separation of 125-I-labelled derivatives of 3′-azido-3′-deoxythymidine

1989 ◽  
Vol 478 (1) ◽  
pp. 280-283
Author(s):  
I Mucha
Keyword(s):  
Chromatographic Separation ◽  
Derivatives Of

scholarly journals Antihyperglycemic agents from Ammannia multiflora

2012 ◽  
Vol 7 (7) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Harish C. Upadhyay ◽  
Natasha Jaiswal ◽  
Akhilesh K. Tamrakar ◽  
Arvind K. Srivastava ◽  
Namita Gupta ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Chromatographic Separation ◽  
Antidiabetic Drug ◽  
Antihyperglycemic Activity ◽  
Chemically Modified ◽  
Isolation And Characterization ◽  
Synthetic Derivatives ◽  
Derivatives Of

The serial chromatographic separation of chloroform and n-butanol fractions of Ammannia multiflora resulted in the isolation and characterization of 4-hydroxy-α-tetralone (1) and 3,3′-(2 R,5 R)-tetrahydrofuran-2,5-diyldiphenol (ammaniol, 2). Compound 1 was chemically modified into six semi-synthetic acyl and aryl derivatives (1A - 1F). The isolated compounds 1 and 2 along with semi-synthetic derivatives 1A - 1F were evaluated for in vitro antihyperglycemic activity employing 2-deoxyglucose uptake by L-6 rat muscle cell lines. The results indicated that both the isolates, as well as derivatives (1A - 1F), have the property to stimulate glucose uptake. Ammaniol (2) increased glucose uptake significantly (64.8%), while one of the aryl derivatives of 1, 4- O-(3,4,5-trimethoxybenzoyl)-α-tetralone (1D), showed potent antihyperglycemic activity and increased glucose uptake by 94.6%, even more than rosiglitazone (88.8%). Further, since 1D possesses better antihyperglycemic activity than rosiglitazone (standard), this might be a new safer antidiabetic drug of herbal origin.

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