Elevated serum aminotransferase activity: An early manifestation of gluten-sensitive enteropathy in children with insulin-dependent diabetes mellitus

1994 ◽  
Vol 124 (6) ◽  
pp. 995 ◽  
Author(s):  
Renata Lorini ◽  
Giuseppe Maggiore ◽  
Costantino De Giacomo ◽  
Letizia Vitali
Keyword(s):  
Diabetes Mellitus ◽  
Elevated Serum ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Aminotransferase Activity ◽  
Serum Aminotransferase ◽  
Gluten Sensitive Enteropathy ◽  
Insulin Dependent ◽  
Early Manifestation

scholarly journals Laron Dwarfism and Non-Insulin-Dependent Diabetes Mellitus in the Hnf-1α Knockout Mouse

1998 ◽  
Vol 18 (5) ◽  
pp. 3059-3068 ◽  
Author(s):  
Ying-Hue Lee ◽  
Brian Sauer ◽  
Frank J. Gonzalez
Keyword(s):  
Diabetes Mellitus ◽  
Elevated Serum ◽  
Insulin Dependent Diabetes Mellitus ◽  
Regulatory Elements ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Null Mouse ◽  
Recombination System ◽  
Igf I ◽  
Insulin Dependent

ABSTRACT Mice deficient in hepatocyte nuclear factor 1 alpha (HNF-1α) were produced by use of the Cre-loxP recombination system. HNF-1α-null mice are viable but sterile and exhibit a phenotype reminiscent of both Laron-type dwarfism and non-insulin-dependent diabetes mellitus (NIDDM). In contrast to an earlier HNF-1α-null mouse line that had been produced by use of standard gene disruption methodology (M. Pontoglio, J. Barra, M. Hadchouel, A. Doyen, C. Kress, J. P. Bach, C. Babinet, and M. Yaniv, Cell 84:575–585, 1996), these mice exhibited no increased mortality and only minimal renal dysfunction during the first 6 months of development. Both dwarfism and NIDDM are most likely due to the loss of expression of insulin-like growth factor I (IGF-I) and lower levels of insulin, resulting in stunted growth and elevated serum glucose levels, respectively. These results confirm the functional significance of the HNF-1α regulatory elements that had previously been shown to reside in the promoter regions of both the IGF-I and the insulin genes.

Elevated serum and urinary thrombomodulin levels in patients with non-insulin-dependent diabetes mellitus

1994 ◽  
Vol 225 (2) ◽  
pp. 89-96 ◽  
Author(s):  
Hitoshi Shimano ◽  
Keiichi Takahashi ◽  
Masanobu Kawakami ◽  
Takanari Gotoda ◽  
Kenji Harada ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Elevated Serum ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

The prevalence of manifest and latent gluten sensitive enteropathy in insulin dependent diabetes mellitus

2000 ◽  
Vol 118 (4) ◽  
pp. A367
Author(s):  
Serkan Guvenc ◽  
Sabahattin Kaymakoglu ◽  
Nuray Gurel Polat ◽  
Kubilay Karsidag ◽  
Kadir Demir ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Gluten Sensitive Enteropathy ◽  
Insulin Dependent
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