RE: A CASE OF CUSHING'S SYNDROME DUE TO ADRENOCORTICAL CARCINOMA WITH RECURRENCE 19 MONTHS AFTER LAPAROSCOPIC ADRENALECTOMY

ABSTRACT A modified method for the estimation of urinary pregnanetriol, pregnanetriol, pregnanetriolone, Δ5-pregnenetriol and tetrahydro S was investigated. The steroids, separated by chromatography, were measured quantitatively, tetrahydro S by reaction with blue tetrazolium and the other three as acetaldehydogenic substances. The excretion of these steroids was studied in suspected instances of adrenal and/or ovarian disease. Urinary pregnanetriol and tetrahydro S levels were normal in Cushing's syndrome, secondary adrenocortical carcinoma, the Stein-Leventhal syndrome, idiopathic hirsutism and hypertension. Tetrahydro S was doubtfully elevated in an instance of ectopic ACTH Cushing's syndrome. Pregnanetriol excretion was elevated in untreated cases of congenital adrenal hyperplasia and after treatment in some. Pregnanetriolone was found in all patients with congenital adrenal hyperplasia, including those receiving cortisone. Pregnanetriolone was also detected in Cushing's syndrome, secondary adrenocortical carcinoma, the Stein-Leventhal syndrome, ectopic ACTH Cushing's syndrome and suspected congenital adrenal hyperplasia. Δ5-pregnenetriol was present as a glucuronide in the Stein-Leventhal syndrome and idiopathic hirsutism. The diagnostic implications of these results are discussed.

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Virilizing adrenocortical carcinoma with Cushing’s syndrome in a 14 months old child

The Indian Journal of Pediatrics ◽

10.1007/bf02776440 ◽

1984 ◽

Vol 51 (4) ◽

pp. 497-500 ◽

Cited By ~ 1

Author(s):

S. Garg ◽

R. K. Marwaha ◽

I. C. Pathak ◽

R. J. Dash

Keyword(s):

Cushing’S Syndrome ◽

Adrenocortical Carcinoma ◽

Cushing's Syndrome

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Role for laparoscopic adrenalectomy in patients with Cushing's syndrome

Arquivos Brasileiros de Endocrinologia & Metabologia ◽

10.1590/s0004-27302007000800021 ◽

2007 ◽

Vol 51 (8) ◽

pp. 1349-1354 ◽

Cited By ~ 7

Author(s):

William F. Young, Jr. ◽

Geoffrey B. Thompson

Keyword(s):

Surgical Management ◽

Cushing’S Syndrome ◽

Patient Selection ◽

Laparoscopic Adrenalectomy ◽

Laparoscopic Approach ◽

Cushing's Syndrome ◽

Open Adrenalectomy ◽

The Past ◽

Tissue Handling

Laparoscopic adrenalectomy is one of the most clinically important advances in the past 2 decades for the treatment of adrenal disorders. When compared to open adrenalectomy, laparoscopic adrenalectomy is equally safe, effective, and curative; it is more successful in shortening hospitalization and convalescence and has less long-term morbidity. The laparoscopic approach to the adrenal is the procedure of choice for the surgical management of cortisol-producing adenomas and for patients with corticotropin (ACTH) dependent Cushing's syndrome for whom surgery failed to remove the source of ACTH. The keys to successful laparoscopic adrenalectomy are appropriate patient selection, knowledge of anatomy, delicate tissue handling, meticulous hemostasis, and experience with the technique of laparoscopic adrenalectomy.

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