1383: Increased DNA Fragmentation in Sperm From Men with Spinal Cord Injury (SCI) as Determined by the Sperm Chromatin Structure Assay (SCSA)

2004 ◽  
Vol 171 (4S) ◽  
pp. 364-364 ◽  
Author(s):  
Jason A. Grotas ◽  
Charles M. Lynne ◽  
Teodoro C. Aballa ◽  
Kjersten L. Larson-Cook ◽  
Harold F. Rodriquez ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Dna Fragmentation ◽  
Chromatin Structure ◽  
Sperm Chromatin ◽  
Sperm Chromatin Structure Assay ◽  
Cord Injury

Evaluating human sperm DNA integrity: relationship between 8-hydroxydeoxyguanosine quantification and the sperm chromatin structure assay

Zygote ◽  
2003 ◽  
Vol 11 (4) ◽  
pp. 367-371 ◽  
Author(s):  
Isabelle Oger ◽  
Christelle Da Cruz ◽  
Gilles Panteix ◽  
Yves Menezo
Keyword(s):  
Dna Fragmentation ◽  
Chromatin Structure ◽  
Inverse Relationship ◽  
Sperm Concentration ◽  
Sperm Chromatin ◽  
Sperm Chromatin Structure Assay ◽  
Fragmentation Index ◽  
Sperm Dna ◽  
Oxidative Products ◽  
Dna Fragmentation Index

In our work, we have used 8-hydroxy-deoxyguanosine (8-OH-dG), one of the major oxidative products of sperm DNA, in a population of patients consulting for infertility. We found an inverse relationship between sperm concentration and the log of the ratio of 8-OH-dG to dG (P<0.01). On the same patients' sperm samples, the sperm chromatin structure assay (SCSA) was performed. An inverse relationship was observed between the DNA fragmentation index and sperm concentration (P<0.001). There was also a positive relationship between SCSA and log 8-OH-dG/dG. This indicates that DNA fragmentation measured by the SCSA originates in part from oxidative products. In a few patients, antioxidant treatment decreased the DNA fragmentation index below the threshold of 30% that is crucial for subfertility.

scholarly journals Sperm chromatin condensation, DNA integrity, and apoptosis in men with spinal cord injury

2013 ◽  
Vol 36 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Ali Reza Talebi ◽  
Mohammad Ali Khalili ◽  
Serajodin Vahidi ◽  
Jalal Ghasemzadeh ◽  
Nasim Tabibnejad
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chromatin Condensation ◽  
Sperm Chromatin ◽  
Dna Integrity ◽  
Cord Injury ◽  
Sperm Chromatin Condensation
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