Synthesis and characterization of glycerol dimethacrylate cross-linked polymethyl methacrylate: a resin for solid phase peptide synthesis

Polymer ◽  
2003 ◽  
Vol 44 (4) ◽  
pp. 911-922 ◽  
Author(s):  
M. Roice ◽  
K.P. Subhashchandran ◽  
A.V. Gean ◽  
J. Franklin ◽  
V.N. Rajasekharan Pillai
Keyword(s):  
Polymethyl Methacrylate ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Synthesis And Characterization

Synthesis and Characterization of Bradykinin Derivatives Based on a β-Cyclodextrin Core

2016 ◽  
Vol 69 (3) ◽  
pp. 328 ◽  
Author(s):  
Rachel J. Stephenson ◽  
Fran Wolber ◽  
Paul G. Plieger ◽  
David R. K. Harding
Keyword(s):  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Synthesis And Characterization ◽  
Structure Activity ◽  
Fmoc Spps ◽  
Model Drug ◽  
Sulfonamide Group ◽  
Important Structure

Mono-6A-fluorenylmethyloxycarbonylamino-mono-6X-succinyl-β-cyclodextrin (1), an amino acid-based bi-functionalized derivative of β-cyclodextrin (β-CD), has been functionalized with the bioactive peptide, bradykinin and/or sulfonamides using fluorenylmethyloxycarbonyl (Fmoc) solid phase peptide synthesis (SPPS). The all-in-one molecule contains a carrier (cyclodextrin), targeting agent (bradykinin), and/or model drug (sulfonamide). Varying combinations of these bradykinin-focussed molecules have been synthesized using Fmoc SPPS on Rink amide resin. The positioning of the sulfonamide group, the bradykinin peptide and the cyclodextrin carrier are essential for biological activity. The inclusion of spacers is also important. Structure–activity studies performed on three cancer cell lines in vitro support these conclusions.

A Strategy for Thioamide Incorporation During Fmoc Solid-Phase Peptide Synthesis with Robust Stereochemical Integrity

2019 ◽  
Author(s):  
luis camacho III ◽  
Bryan J. Lampkin ◽  
Brett VanVeller
Keyword(s):  
Amino Acid ◽  
Functional Groups ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Side Chains ◽  
Amino Acid Side Chains ◽  
Peptide Elongation

We describe a method to protect the sensitive stereochemistry of the thioamide—in analogy to the protection of the functional groups of amino acid side chains—in order to preserve the thioamide moiety during peptide elongation.<br>

Analytical Methods for Solid Phase Peptide Synthesis

2004 ◽  
Vol 8 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Giuseppina Sabatino ◽  
Mario Chelli ◽  
Alberto Brandi ◽  
Anna Papini
Keyword(s):  
Peptide Synthesis ◽  
Analytical Methods ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis
Sign in / Sign up

Export Citation Format

Share Document