Mechanistic Studies in the Radical Induced DNA Strand Cleavage—Formation and Reactivity of the Radical Cation Intermediate

Tetrahedron ◽  
2000 ◽  
Vol 56 (25) ◽  
pp. 4117-4128 ◽  
Author(s):  
Ralf Glatthar ◽  
Martin Spichty ◽  
Andreas Gugger ◽  
Rohit Batra ◽  
Wolfgang Damm ◽  
...  
Keyword(s):  
Radical Cation ◽  
Mechanistic Studies ◽  
Dna Strand

ChemInform Abstract: Mechanistic Studies in the Radical Induced DNA Strand Cleavage - Formation and Reactivity of the Radical Cation Intermediate.

ChemInform ◽  
2000 ◽  
Vol 31 (39) ◽  
pp. no-no
Author(s):  
Ralf Glatthar ◽  
Martin Spichty ◽  
Andreas Gugger ◽  
Rohit Batra ◽  
Wolfgang Damm ◽  
...  
Keyword(s):  
Radical Cation ◽  
Mechanistic Studies ◽  
Dna Strand

scholarly journals Mechanistic Studies on TiO2 Photoelectrochemical Radical Cation [2 + 2] Cycloadditions

2020 ◽  
Vol 167 (15) ◽  
pp. 155529
Author(s):  
Genki Horiguchi ◽  
Hidehiro Kamiya ◽  
Yohei Okada
Keyword(s):  
Radical Cation ◽  
Mechanistic Studies

scholarly journals Mechanistic Studies of Ce(IV)-Mediated Oxidation of β-Dicarbonyls:  Solvent-Dependent Behavior of Radical Cation Intermediates

2007 ◽  
Vol 72 (15) ◽  
pp. 5486-5492 ◽  
Author(s):  
Jingliang Jiao ◽  
Yang Zhang ◽  
James J. Devery ◽  
Luna Xu ◽  
Jennifer Deng ◽  
...  
Keyword(s):  
Radical Cation ◽  
Mechanistic Studies ◽  
Dependent Behavior ◽  
Mediated Oxidation

scholarly journals Organic Photoredox Catalyzed Direct Hydroamination of Ynamides with Azoles

2021 ◽  
Author(s):  
Yongming Deng ◽  
Ban Wang ◽  
Gavin Mccabe ◽  
Mitchell Parrish ◽  
Jujhar Singh ◽  
...  
Keyword(s):  
Radical Cation ◽  
Direct Method ◽  
Single Electron ◽  
Mechanistic Studies ◽  
System A ◽  
A Direct Method

Disclosed herein is a novel photoinduced selective hydroamination of ynamides with nitrogen heteroaromatic nucleophiles. By using an organocatalytic photoredox system, a direct method to construct a diverse of (Z)-α-azole enamides from ynamides and pyrazoles, as well as triazoles, benzotriazoles, indazoles, and tetrazoles, is developed, thus providing a concise route to heterocyclic motifs common in medicinal agents. Based on the mechanistic studies, the hydroamination is postulated to operate via a mechanism in which the single-electron oxidation of ynamide and the intermediacy of an alkyne radical cation, is responsible for the observed reactivity.

scholarly journals Electrochemical C-C Bond Cleavage of Cyclopropanes towards the Synthesis of 1,3-Difunctionalized Molecules

2020 ◽  
Author(s):  
Pan Peng ◽  
Xingxiu Yan ◽  
Ke Zhang ◽  
Zhao Liu ◽  
Li Zeng ◽  
...  
Keyword(s):  
Functional Groups ◽  
Organic Synthesis ◽  
Radical Cation ◽  
Redox Reactions ◽  
Bond Cleavage ◽  
Strategic Choice ◽  
Mechanistic Studies ◽  
Catalyst Free ◽  
Electrochemical Condition ◽  
Anode Oxidation

Abstract Electrochemistry had a lot of inherent advantages in organic synthesis and many redox reactions have been achieved under electrochemical condition. However, the electrochemical C-C bond cleavage and functionalization reactions are less studied. Here we developed electrochemical C-C bond cleavage and 1,3-difuntionalization of arylcyclopropanes under catalyst-free and external-oxidant-free conditions. 1,3-difluorination, 1,3-oxyfluorination and 1,3-dioxygenation of arylcyclopropanes were achieved with a highly chemo- and regioselectivity by the strategic choice of nucleophiles. This protocol has good functional groups tolerance and can be scaled up. Mechanistic studies demonstrate that arylcyclopropane radical cation yielded from the anode oxidation and the following generated benzyl carbonium are the key intermediates in this transformation. This development provides a new scenario for constructing 1,3-difunctionalized molecules.

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