A bay-region-selective annulative π-extension (APEX) reaction of perylene diimides (PDIs) has been achieved by means of in-situ generated reactive aryne intermediates. This method provides an efficient one-pot π-extension at the short axis of PDIs in a sequential manner. Mechanistically, an inverse-electron-demand Diels–Alder reaction might be operative for the transformation.
We report site-specific triple click labeling for DNA and RNA in a one-pot setup by performing inverse electron demand Diels–Alder reaction and strain-promoted and copper catalyzed click reactions sequentially.
One-pot, scalable synthesis of symmetrical and unsymmetrical 2,4,6-triarylpyrylium ions via a highly regioselective inverse electron demand Diels–Alder (IEDDA) reaction.
Sn-PILC: A novel efficient and recyclable catalyst for one-pot three component Povarov’s inverse-electron-demand hetero Diels-Alder reaction for a facile synthesis of tetrahydropyranoquinoline derivatives under neat conditions.