An efficient synthesis of methyl N-[2-(R)-(1-napthylmethyl)-3-(morpholinocarbonyl)propionyl]-(S)-histidinate, the key synthetic intermediate of renin inhibitors

1990 ◽  
Vol 31 (19) ◽  
pp. 2731-2734 ◽  
Author(s):  
Yoshio Ito ◽  
Tetsuhide Kamijo ◽  
Hiromu Harada ◽  
Fuyuhiko Matsuda ◽  
Shire Terashima
Keyword(s):  
Efficient Synthesis ◽  
Renin Inhibitors ◽  
Synthetic Intermediate

Efficient Synthesis of 5-Alkoxy-(3R)-hydroxy-2,3-dihydrospiro[indene-1,4′-piperidines]: A Novel Scaffold for Renin Inhibitors

Synlett ◽  
2009 ◽  
Vol 2009 (15) ◽  
pp. 2521-2523
Author(s):  
Takahide Nishi ◽  
Yuji Nakamura ◽  
Takaaki Jojima ◽  
Chie Suzuki ◽  
Shojiro Miyazaki
Keyword(s):  
Efficient Synthesis ◽  
Renin Inhibitors ◽  
Novel Scaffold

Approaches to the synthesis of triterpenoids. VI. The synthesis of 3,3,10aβ-trimethyl-l,2,3,4,4aβ,5,8,9,10,10a-decahydrophenanthren-7(6H)-one, a potential intermediate for pentacyclic triterpene synthesis

1981 ◽  
Vol 59 (6) ◽  
pp. 1010-1017 ◽  
Author(s):  
John W. ApSimon ◽  
David Moir ◽  
Kazuyuki Yamasaki
Keyword(s):  
Nmr Spectra ◽  
Efficient Synthesis ◽  
Pentacyclic Triterpene ◽  
Naturally Occurring ◽  
Ring Junction ◽  
Triterpene Synthesis ◽  
Synthetic Intermediate ◽  
Related Compounds ◽  
C Nmr

Investigations of the CDE ring construction of naturally occurring triterpenoids are described. The efficient synthesis of 3,3,10aβ-trimethyl-1,2,3,4,4aβ,5,8,9,10,10a-decahydrophenanthren-7(6H)-one(25) has been achieved. The D/E ring junction of the molecule, as well as that of related compounds, has been established by the use of 13C nmr spectra. The synthetic intermediate 25 can be considered as a key substance for a synthetic entry to friedelin (1) in addition to β-amyrin (23).

Short and Efficient Synthesis of Protected (2S,3R,4S)-2-Amino-1-cyclohexyl-3,4-alkane-diols: C-Terminal Components of Renin Inhibitors

Synlett ◽  
1993 ◽  
Vol 1993 (02) ◽  
pp. 153-154 ◽  
Author(s):  
Heinz-Werner Kleemann ◽  
Gerhard Beck ◽  
Holger Heitsch ◽  
Heiner Jendralla ◽  
Remo Weck ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Renin Inhibitors

ChemInform Abstract: Short and Efficient Synthesis of Protected (2S,3R,4S)-2-Amino-1- cyclohexyl-3,4-alkanediols: C-Terminal Components of Renin Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 25 (16) ◽  
pp. no-no
Author(s):  
H.-W. KLEEMANN ◽  
G. BECK ◽  
H. HEITSCH ◽  
H. JENDRALLA ◽  
R. WECK ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Renin Inhibitors

ChemInform Abstract: Efficient Synthesis of 5-Amino-6-dialkylamino-4-hydroxypentanamide Derivatives for Renin Inhibitors.

ChemInform ◽  
2011 ◽  
Vol 42 (46) ◽  
pp. no-no
Author(s):  
Yuji Nakamura ◽  
Yasuyuki Ogawa ◽  
Chie Suzuki ◽  
Teppei Fujimoto ◽  
Shojiro Miyazaki ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Renin Inhibitors

ChemInform Abstract: Unique and Efficient Synthesis of (2S-(2R*,3S*,4R*))-2-Amino-1- cyclohexyl-6-methyl-3,4-heptanediol, a Popular C-Terminal Component of Many Renin Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 28 (21) ◽  
pp. no-no
Author(s):  
M. A. SCHWINDT ◽  
D. T. BELMONT ◽  
M. CARLSON ◽  
L. C. FRANKLIN ◽  
V. S. HENDRICKSON ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Renin Inhibitors ◽  
Terminal Component

Efficient Synthesis of 5-Amino-6-dialkylamino-4-hydroxypentanamide Derivatives for Renin Inhibitors

Heterocycles ◽  
2011 ◽  
Vol 83 (7) ◽  
pp. 1587 ◽  
Author(s):  
Yuji Nakamura ◽  
Chie Suzuki ◽  
Teppei Fujimoto ◽  
Shojiro Miyazaki ◽  
Kazuhiko Tamaki ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Renin Inhibitors

Unique and Efficient Synthesis of [2S-(2R*,3S*,4R*)]-2-Amino-1-cyclohexyl- 6-methyl-3,4-heptanediol, a Popular C-Terminal Component of Many Renin Inhibitors

1996 ◽  
Vol 61 (26) ◽  
pp. 9564-9568 ◽  
Author(s):  
Mark A. Schwindt ◽  
Daniel T. Belmont ◽  
Mark Carlson ◽  
Lloyd C. Franklin ◽  
Valerie S. Hendrickson ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Renin Inhibitors ◽  
Terminal Component

Efficient Synthesis of 4,5,9,10-Tetrahydropyrene:  A Useful Synthetic Intermediate for the Synthesis of 2,7-Disubstituted Pyrenes

1999 ◽  
Vol 64 (18) ◽  
pp. 6888-6890 ◽  
Author(s):  
Daniel M. Connor ◽  
Scott D. Allen ◽  
David M. Collard ◽  
Charles L. Liotta ◽  
David A. Schiraldi
Keyword(s):  
Efficient Synthesis ◽  
Synthetic Intermediate
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