Increased expression of glucocorticoid receptor β in lymphocytes of patients with severe atopic dermatitis unresponsive to topical corticosteroid

2011 ◽  
Vol 2011 ◽  
pp. 65-66
Author(s):  
J.Q. Del Rosso ◽  
G.K. Kim
Keyword(s):  
Atopic Dermatitis ◽  
Glucocorticoid Receptor ◽  
Topical Corticosteroid ◽  
Severe Atopic Dermatitis

Cataract and Retinal Detachment in Patients with Severe Atopic Dermatitis Who Were Withdrawn from the Use of Topical Corticosteroid

1999 ◽  
Vol 26 (10) ◽  
pp. 658-665 ◽  
Author(s):  
Hiroko Taniguchi ◽  
Orina Ohki ◽  
Hiroo Yokozeki ◽  
Ichiro Katayama ◽  
Akiko Tanaka ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Retinal Detachment ◽  
Topical Corticosteroid ◽  
Severe Atopic Dermatitis

Protein-losing enteropathy in an infant with severe atopic dermatitis

2021 ◽  
Vol 14 (4) ◽  
pp. e241057
Author(s):  
Yuji Fujita ◽  
Kohei Nomura ◽  
Shigemi Yoshihara
Keyword(s):  
Atopic Dermatitis ◽  
Serum Albumin ◽  
Topical Corticosteroid ◽  
Urine Volume ◽  
Male Infant ◽  
Corticosteroid Treatment ◽  
Severe Atopic Dermatitis ◽  
Protein Losing Enteropathy ◽  
Protein Levels ◽  
Recurrent Vomiting

Severe atopic dermatitis (AD) may lead to various complications such as hypoproteinaemia. We describe the case of a 7-month-old male infant with severe AD complicated with protein-losing enteropathy (PLE). He was diagnosed with AD at 2 months of age; however, because of familial steroid phobia, topical corticosteroids were not administered. At 7 months of age, he was admitted to our hospital for decreased feeding, diarrhoea, reduced urine volume and recurrent vomiting. Class 3 topical corticosteroid treatment was initiated. On day 3, eczema had almost resolved. However, serum protein levels had not improved; oliguria persisted and oedema worsened. Serum albumin scintigraphy revealed radioisotopes in the distal duodenum, leading to PLE diagnosis. Systemic prednisolone and albumin were administered, with no PLE relapse after discontinuation. To our knowledge, only two infant PLE cases associated with AD were reported to date. PLE should be considered in patients with severe AD and persistent hypoproteinaemia.

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