Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial

Simon Heller; John Buse; Miles Fisher; Satish Garg; Michel Marre; Ludwig Merker; Eric Renard; David Russell-Jones; Areti Philotheou; Ann Marie Ocampo Francisco; Huiling Pei; Bruce Bode

doi:10.1016/s0140-6736(12)60204-9

Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial

The Lancet ◽

10.1016/s0140-6736(12)60204-9 ◽

2012 ◽

Vol 379 (9825) ◽

pp. 1489-1497 ◽

Cited By ~ 221

Author(s):

Simon Heller ◽

John Buse ◽

Miles Fisher ◽

Satish Garg ◽

Michel Marre ◽

...

Keyword(s):

Type 1 Diabetes ◽

Insulin Glargine ◽

Insulin Aspart ◽

Insulin Degludec ◽

Treat To Target ◽

Open Label ◽

Phase 3 ◽

Mealtime Insulin ◽

Basal Bolus

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Comparison of insulin detemir and insulin glargine in a basal—bolus regimen, with insulin aspart as the mealtime insulin, in patients with type 1 diabetes: A 52-week, multinational, randomized, open-label, parallel-group, Treat-to-Target noninferiority trial

Clinical Therapeutics ◽

10.1016/j.clinthera.2009.10.006 ◽

2009 ◽

Vol 31 (10) ◽

pp. 2086-2097 ◽

Cited By ~ 60

Author(s):

Simon Heller ◽

Christoph Koenen ◽

Bruce Bode

Keyword(s):

Type 1 Diabetes ◽

Insulin Glargine ◽

Insulin Aspart ◽

Insulin Detemir ◽

Treat To Target ◽

Open Label ◽

Parallel Group ◽

Mealtime Insulin ◽

Basal Bolus

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Insulin Degludec/Insulin Aspart Administered Once Daily at Any Meal, With Insulin Aspart at Other Meals Versus a Standard Basal-Bolus Regimen in Patients With Type 1 Diabetes: A 26-week, phase 3, randomized, open-label, treat-to-target trial

Diabetes Care ◽

10.2337/dc11-2503 ◽

2012 ◽

Vol 35 (11) ◽

pp. 2174-2181 ◽

Cited By ~ 49

Author(s):

I. B. Hirsch ◽

B. Bode ◽

J.-P. Courreges ◽

P. Dykiel ◽

E. Franek ◽

...

Keyword(s):

Type 1 Diabetes ◽

Insulin Aspart ◽

Insulin Degludec ◽

Treat To Target ◽

Target Trial ◽

Open Label ◽

Phase 3 ◽

Once Daily ◽

Basal Bolus

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Efficacy and safety of insulin degludec given as part of basal–bolus treatment with mealtime insulin aspart in type 1 diabetes: a 26‐week randomized, open‐label, treat‐to‐target non‐inferiority trial

Diabetes Obesity and Metabolism ◽

10.1111/dom.12298 ◽

2014 ◽

Vol 16 (10) ◽

pp. 922-930 ◽

Cited By ~ 29

Author(s):

M. J. Davies ◽

J. L. Gross ◽

Y. Ono ◽

T. Sasaki ◽

G. Bantwal ◽

...

Keyword(s):

Type 1 Diabetes ◽

Insulin Aspart ◽

Insulin Degludec ◽

Treat To Target ◽

Efficacy And Safety ◽

Open Label ◽

Mealtime Insulin ◽

Basal Bolus

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Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial

The Lancet ◽

10.1016/s0140-6736(12)60205-0 ◽

2012 ◽

Vol 379 (9825) ◽

pp. 1498-1507 ◽

Cited By ~ 212

Author(s):

Alan J Garber ◽

Allen B King ◽

Stefano Del Prato ◽

Seamus Sreenan ◽

Mustafa K Balci ◽

...

Keyword(s):

Type 2 Diabetes ◽

Insulin Glargine ◽

Insulin Aspart ◽

Insulin Degludec ◽

Treat To Target ◽

Open Label ◽

Phase 3 ◽

Mealtime Insulin ◽

Basal Bolus

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Insulin degludec improves glycaemic control with lower nocturnal hypoglycaemia risk than insulin glargine in basal–bolus treatment with mealtime insulin aspart in Type 1 diabetes (BEGIN ® Basal–Bolus Type 1): 2‐year results of a randomized clinical trial

Diabetic Medicine ◽

10.1111/dme.12243 ◽

2013 ◽

Vol 30 (11) ◽

pp. 1293-1297 ◽

Cited By ~ 65

Author(s):

B. W. Bode ◽

J. B. Buse ◽

M. Fisher ◽

S. K. Garg ◽

M. Marre ◽

...

Keyword(s):

Clinical Trial ◽

Type 1 Diabetes ◽

Glycaemic Control ◽

Insulin Glargine ◽

Insulin Aspart ◽

Insulin Degludec ◽

Nocturnal Hypoglycaemia ◽

Mealtime Insulin ◽

Basal Bolus

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Safety and efficacy of insulin degludec/insulin aspart with bolus mealtime insulin aspart compared with standard basal-bolus treatment in people with Type 1 diabetes: 1-year results from a randomized clinical trial (BOOST® T1)

Diabetic Medicine ◽

10.1111/dme.13068 ◽

2016 ◽

Vol 34 (2) ◽

pp. 167-173 ◽

Cited By ~ 16

Author(s):

I. B. Hirsch ◽

E. Franek ◽

H. Mersebach ◽

L. Bardtrum ◽

K. Hermansen

Keyword(s):

Clinical Trial ◽

Type 1 Diabetes ◽

Randomized Clinical Trial ◽

Insulin Aspart ◽

Insulin Degludec ◽

Safety And Efficacy ◽

Mealtime Insulin ◽

Basal Bolus

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Comparison of Once- Versus Twice-Daily Administration of Insulin Detemir, Used With Mealtime Insulin Aspart, in Basal-Bolus Therapy for Type 1 Diabetes: Assessment of Detemir Administration in a Progressive Treat-To-Target Trial (ADAPT)

Diabetes Care ◽

10.2337/dc08-0332 ◽

2008 ◽

Vol 32 (1) ◽

pp. 32-37 ◽

Cited By ~ 33

Author(s):

J.-P. Le Floch ◽

M. Levy ◽

H. Mosnier-Pudar ◽

F. Nobels ◽

S. Laroche ◽

...

Keyword(s):

Type 1 Diabetes ◽

Insulin Aspart ◽

Insulin Detemir ◽

Daily Administration ◽

Treat To Target ◽

Target Trial ◽

Mealtime Insulin ◽

Basal Bolus

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Cost-Effectiveness of Insulin Degludec Compared with Insulin Glargine in a Basal-Bolus Regimen in Patients with Type 1 Diabetes Mellitus in the United Kingdom

Value in Health ◽

10.1016/j.jval.2013.08.685 ◽

2013 ◽

Vol 16 (7) ◽

pp. A442

Author(s):

B. Chubb ◽

M. Evans ◽

M. Wolden ◽

T. Christensen ◽

J. Gundgaard

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

United Kingdom ◽

Cost Effectiveness ◽

Insulin Glargine ◽

Type 1 Diabetes Mellitus ◽

Insulin Degludec ◽

The United Kingdom ◽

Basal Bolus

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Cost-effectiveness of insulin degludec compared with insulin glargine in a basal-bolus regimen in patients with type 1 diabetes mellitus in the UK

Journal of Medical Economics ◽

10.3111/13696998.2014.971160 ◽

2014 ◽

Vol 18 (1) ◽

pp. 56-68 ◽

Cited By ~ 26

Author(s):

M. Evans ◽

M. Wolden ◽

J. Gundgaard ◽

B. Chubb ◽

T. Christensen

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Cost Effectiveness ◽

Insulin Glargine ◽

Type 1 Diabetes Mellitus ◽

Insulin Degludec ◽

The Uk ◽

Basal Bolus

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Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: a pre‐planned meta‐analysis of phase 3 trials

Diabetes Obesity and Metabolism ◽

10.1111/dom.12032 ◽

2012 ◽

Vol 15 (2) ◽

pp. 175-184 ◽

Cited By ~ 214

Author(s):

R. E. Ratner ◽

S. C. L. Gough ◽

C. Mathieu ◽

S. Del Prato ◽

B. Bode ◽

...

Keyword(s):

Type 1 Diabetes ◽

Insulin Glargine ◽

Meta Analysis ◽

Insulin Degludec ◽

Phase 3

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