Fetal haemoglobin in sickle-cell disease: from genetic epidemiology to new therapeutic strategies

The Lancet ◽  
2016 ◽  
Vol 387 (10037) ◽  
pp. 2554-2564 ◽  
Author(s):  
Guillaume Lettre ◽  
Daniel E Bauer
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Genetic Epidemiology ◽  
Therapeutic Strategies ◽  
Cell Disease ◽  
Fetal Haemoglobin

Screening for Sickle Cell Disease: A Hospital Based Study in Eastern Odisha, India

2012 ◽  
Vol 2 (2) ◽  
pp. 57-60
Author(s):  
Jayanti Mishra ◽  
Sanghamitra Pati ◽  
Mohammad Akhtar Hussain ◽  
Niraj Srivastava ◽  
Sindhubala Mishra
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Cell Disease ◽  
Medicine Department ◽  
Fetal Haemoglobin ◽  
Medical College ◽  
Rbc Indices ◽  
And Gender ◽  
Cell Gene

The highest frequency of sickle cell gene in India is reported in Odisha. The present study was taken up to assess the presence of sickle cell disease among febrile patients of a medical college of eastern Odisha. Patients referred from both pediatric and medicine department to the Hematology section of the department of Pathology, SCB Medical College, Cuttack were subjected to measurement of RBC indices, Sickling test, Haemoglobin Electrophoresis and Fetal Haemoglobin Estimation. Out of total 1000 referred patients 76(7.6%) were found to be positive for sickling. Two‐third of sicklingpositive patients had sickle cell trait with electrophoretic AS band. There was a significant association between age and positive sickling (χ2 = 24.357; df = 4, P = <0.0001). No significant association was observed between sickling and gender. Sickle cell positive cases are not uncommon in eastern Odisha. Our study demonstrated sickle cell trait to be more common among screened patients than other forms of sickle cell diseases.

scholarly journals Therapeutic strategies for sickle cell disease: towards a multi-agent approach

2018 ◽  
Vol 18 (2) ◽  
pp. 139-158 ◽  
Author(s):  
Marilyn J. Telen ◽  
Punam Malik ◽  
Gregory M. Vercellotti
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Therapeutic Strategies ◽  
Cell Disease ◽  
Multi Agent

Post-natal decline of fetal haemoglobin in homozygous sickle cell disease: relationship to parental Hb F levels

1982 ◽  
Vol 52 (3) ◽  
pp. 455-463 ◽  
Author(s):  
Karlene P. Mason ◽  
Yvonne Grandison ◽  
R. J. Hayes ◽  
Beryl E. Serjeant ◽  
G.R. Serjeant ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Fetal Haemoglobin ◽  
Homozygous Sickle Cell Disease

Fetal haemoglobin and pregnancy in homozygous sickle cell disease

1989 ◽  
Vol 72 (3) ◽  
pp. 434-438 ◽  
Author(s):  
David T. Dunn ◽  
Damayanti Poddar ◽  
Beryl E. Serjeant ◽  
Graham R. Serjeant
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Fetal Haemoglobin ◽  
Homozygous Sickle Cell Disease

Oxidative stress in sickle cell disease: An overview of erythrocyte redox metabolism and current antioxidant therapeutic strategies

2013 ◽  
Vol 65 ◽  
pp. 1101-1109 ◽  
Author(s):  
Danilo Grunig Humberto Silva ◽  
Edis Belini Junior ◽  
Eduardo Alves de Almeida ◽  
Claudia Regina Bonini-Domingos
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Therapeutic Strategies ◽  
Cell Disease ◽  
Redox Metabolism

scholarly journals Fetal haemoglobin and early manifestations of homozygous sickle cell disease.

1992 ◽  
Vol 67 (4) ◽  
pp. 517-520 ◽  
Author(s):  
K Bailey ◽  
J S Morris ◽  
P Thomas ◽  
G R Serjeant
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Fetal Haemoglobin ◽  
Homozygous Sickle Cell Disease

Turning Back the Sickle Cell Disease: A New Drug into Play

2021 ◽  
Author(s):  
Satashree Paul ◽  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Drug Candidate ◽  
Cell Disease ◽  
Fetal Haemoglobin ◽  
New Drug

Researchers at the Fulcrum Therapeutics developed a bioavailable drug candidate called FTX 6058 – (a novel small molecular fetal haemoglobin inducer for sickle cell disease) that can restore the body’s ability to produce fetal haemoglobin

scholarly journals Elevated fetal haemoglobin levels are associated with decreased incidence of retinopathy in adults with sickle cell disease

2018 ◽  
Vol 183 (5) ◽  
pp. 807-811 ◽  
Author(s):  
Umar K. Mian ◽  
Joyce Tang ◽  
Ana P. M. Allende ◽  
Moonseong Heo ◽  
Nicole Bernstein ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Fetal Haemoglobin
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