new drug
Recently Published Documents


TOTAL DOCUMENTS

4367
(FIVE YEARS 738)

H-INDEX

93
(FIVE YEARS 9)

2022 ◽  
Vol 44 (1) ◽  
pp. 34-34
Author(s):  
Sarah DiGiulio
Keyword(s):  

Pharmacia ◽  
2022 ◽  
Vol 69 (1) ◽  
pp. 51-59
Author(s):  
Porkodi Ayyar ◽  
Umamaheswari Subramanian

Drug repurposing refers to finding new indications for existing drugs. The paradigm shift from traditional drug discovery to drug repurposing is driven by the fact that new drug pipelines are getting dried up because of mounting Research & Development (R&D) costs, long timeline for new drug development, low success rate for new molecular entities, regulatory hurdles coupled with revenue loss from patent expiry and competition from generics. Anaemic drug pipelines along with increasing demand for newer effective, cheaper, safer drugs and unmet medical needs call for new strategies of drug discovery and, drug repurposing seems to be a promising avenue for such endeavours. Drug repurposing strategies have progressed over years from simple serendipitous observations to more complex computational methods in parallel with our ever-growing knowledge on drugs, diseases, protein targets and signalling pathways but still the knowledge is far from complete. Repurposed drugs too have to face many obstacles, although lesser than new drugs, before being successful.


2022 ◽  
Vol 122 (1) ◽  
pp. 21-21
Author(s):  
Diane S. Aschenbrenner
Keyword(s):  

2022 ◽  
Vol 126 ◽  
pp. 104258
Author(s):  
Diletta Punginelli ◽  
Domenico Schillaci ◽  
Manuela Mauro ◽  
Alan Deidun ◽  
Giampaolo Barone ◽  
...  

2022 ◽  
Vol 37 (1) ◽  
pp. 1-3
Author(s):  
Chris Alderman
Keyword(s):  

2022 ◽  
Vol Volume 16 ◽  
pp. 23-66
Author(s):  
Nurul Amirah Mohd Zaid ◽  
Mahendran Sekar ◽  
Srinivasa Reddy Bonam ◽  
Siew Hua Gan ◽  
Pei Teng Lum ◽  
...  

2022 ◽  
Vol 27 ◽  
pp. 2515690X2110536
Author(s):  
Samaneh Soleymani ◽  
Ayeh Naghizadeh ◽  
Mehrdad Karimi ◽  
Azadeh Zarei ◽  
Raefeh Mardi ◽  
...  

The coronavirus disease-2019 (COVID-19) pandemic started in early 2020 with the outbreak of a highly pathogenic human coronavirus. The world is facing a challenge and there is a pressing need for efficient drugs. Plants and natural compounds are a proven rich resource for new drug discovery. Considering the potential of natural products to manage the pandemic, this article was designed to provide an inclusive map of the stages and pathogenetic mechanisms for effective natural products on COVID-19. New drug discovery for the COVID-19 pandemic can encompass both prevention and disease management strategies. Preventive mechanisms that may be considered include boosting the immune response and hand hygiene in the preexposure phase; and blocking of virus binding and entry in the postexposure phase. Potential therapeutic target mechanisms include virus-directed therapies and host-directed therapies. Several medicinal plants and natural products, such as Withania somnifera (L.) Dunal and propolis for prevention; Tanacetum parthenium (L.) for treatment; and Ammoides verticillata (Desf.) Briq and Nigella sativa L. for both prevention and treatment have been found effective and are good targets for future research. The examples of phytochemical compounds that may be effective include aloin and terpenes as anti-septics; isothymol, dithymoquinone, and glycyrrhizin as inhibitors of virus binding and entry; glycyrrhizin, and berberine as replication suppressants; ginsenoside Rg1 and parthenolide as immunomodulators; and eriocitrin, rhoifolin, hesperidin, naringin, rutin, and veronicastroside as anti-complements. Recognizing different mechanisms of fighting against this virus can lead to a more systematic approach in finding natural products and medicinal plants for COVID-19 prevention and treatment.


2021 ◽  
Vol 19 ◽  
Author(s):  
Sunita Kumari ◽  
Rajnish Kumar ◽  
Avijit Mazumder ◽  
Salahuddin ◽  
Shivani Saxena ◽  
...  

Abstract: Among the large variety of nitrogen and oxygen-containing heterocycles, 1,3,4-oxadiazole, the scaffold, has attracted considerable attention owing to its ability to show an extensive range of pharmacological actions. According to literature investigations, prepared 1,3,4-oxadiazole and its derivative are pharmacologically significant and consist of a variety of activities, such as anticonvulsant, anticancer, antioxidant, anti-inflammatory, antibacterial, antidiabetic, etc. These heterocyclics are formed mainly by the cyclization reactions of various reactants under diverse reaction circumstances. Therefore, significant efforts of organic chemists have been directed towards the synthesis of new drug candidates containing 1,3,4-oxadiazole subunits connected to an established potential pharmacophore to improve the efficacy and potency. This article aims to highlight recent publications on the various synthesis techniques of 1,3,4-oxadiazole and related compounds over the previous ten years (2011–2021). The purpose of this review is to help researchers by summarizing several synthetic strategies for synthesizing oxadiazole.


Sign in / Sign up

Export Citation Format

Share Document