2-Halopropionic Acid-induced Cerebellar Granule Cell Necrosis in the Rat: In Vivo and In Vitro Studies

NeuroToxicology ◽

10.1016/s0161-813x(01)00027-4 ◽

2001 ◽

Vol 22 (3) ◽

pp. 363-374 ◽

Author(s):

Edward A Lock ◽

Andrew Gyte ◽

Nicholas C Sturgess ◽

Stephen Duffell ◽

Ian Wyatt

Keyword(s):

Granule Cell ◽

Cerebellar Granule Cell ◽

In Vitro Studies ◽

Cell Necrosis ◽

Cerebellar Granule ◽

Cerebellar Granule Cell Necrosis

Download Full-text

l -2-Chloropropionic acid-induced cerebellar granule cell necrosis is potentiated by L-type calcium channel antagonists

Archives of Toxicology ◽

10.1007/s002040050457 ◽

1997 ◽

Vol 71 (12) ◽

pp. 751-755 ◽

Author(s):

P. S. Widdowson ◽

A. Gyte ◽

R. Upton ◽

J. C. E. Smith ◽

M. Pitts ◽

...

Keyword(s):

Calcium Channel ◽

Granule Cell ◽

Cerebellar Granule Cell ◽

Cell Necrosis ◽

Calcium Channel Antagonists ◽

Cerebellar Granule ◽

Cerebellar Granule Cell Necrosis

Download Full-text

The role of glutathione in L -2-chloropropionic acid induced cerebellar granule cell necrosis in the rat

Archives of Toxicology ◽

10.1007/s002040050333 ◽

1996 ◽

Vol 70 (11) ◽

pp. 724-735 ◽

Author(s):

I. Wyatt ◽

Andrew Gyte ◽

Michael G. Simpson ◽

Peter S. Widdowson ◽

Edward A. Lock

Keyword(s):

Granule Cell ◽

Cerebellar Granule Cell ◽

Cell Necrosis ◽

Cerebellar Granule ◽

Cerebellar Granule Cell Necrosis

Download Full-text

The absence of cerebellar granule cell necrosis in the mouse following L- 2-chloropropionic acid administration

Archives of Toxicology ◽

10.1007/s002040000160 ◽

2000 ◽

Vol 74 (9) ◽

pp. 547-554 ◽

Author(s):

Edward A. Lock ◽

Andrew Gyte ◽

Stephen Duffell ◽

Ian Wyatt

Keyword(s):

Granule Cell ◽

Cerebellar Granule Cell ◽

Cell Necrosis ◽

Cerebellar Granule ◽

Cerebellar Granule Cell Necrosis ◽

Acid Administration

Download Full-text

Neuroprotection afforded by MK-801 against l-2-chloropropionic acid-induced cerebellar granule cell necrosis in the rat

10.1016/s0300-483x(97)00104-2 ◽

1997 ◽

Vol 123 (1-2) ◽

pp. 41-51 ◽

Author(s):

Edward A Lock ◽

Andrew Gyte ◽

Stephen J Duffell ◽

Michael G Simpson ◽

Ian Wyatt

Keyword(s):

Granule Cell ◽

Cerebellar Granule Cell ◽

Cell Necrosis ◽

Cerebellar Granule ◽

Mk 801 ◽

Cerebellar Granule Cell Necrosis

Download Full-text

Chloropropionic acid-induced alterations in glucose metabolic status: possible relevance to cerebellar granule cell necrosis

Archives of Toxicology ◽

10.1007/s002040050225 ◽

1995 ◽

Vol 69 (9) ◽

pp. 640-643 ◽

Author(s):

Edward A. Lock ◽

Andrew Gyte ◽

Peter Widdowson ◽

Michael Simpson ◽

Ian Wyatt

Keyword(s):

Granule Cell ◽

Cerebellar Granule Cell ◽

Metabolic Status ◽

Cell Necrosis ◽

Cerebellar Granule ◽

Cerebellar Granule Cell Necrosis

Download Full-text

Glutathione depletion in the liver and brain produced by 2-chloropropionic acid: relevance to cerebellar granule cell necrosis

Archives of Toxicology ◽

10.1007/s002040050289 ◽

1996 ◽

Vol 70 (6) ◽

pp. 380-389 ◽

Author(s):

I. Wyatt ◽

Andrew Gyte ◽

G. Mainwaring ◽

Peter S. Widdowson ◽

E. A. Lock

Keyword(s):

Granule Cell ◽

Cerebellar Granule Cell ◽

Glutathione Depletion ◽

Cell Necrosis ◽

Cerebellar Granule ◽

Cerebellar Granule Cell Necrosis

Download Full-text

Possible role of nitric oxide in the development of L-2-chloropropionic acid-induced cerebellar granule cell necrosis

British Journal of Pharmacology ◽

10.1111/j.1476-5381.1996.tb15351.x ◽

1996 ◽

Vol 117 (8) ◽

pp. 1761-1767 ◽

Author(s):

P.S. Widdowson ◽

A. Gyte ◽

M.G. Simpson ◽

M. Farnworth ◽

D. Dunn ◽

...

Keyword(s):

Nitric Oxide ◽

Granule Cell ◽

Cerebellar Granule Cell ◽

Cell Necrosis ◽

Cerebellar Granule ◽

Cerebellar Granule Cell Necrosis

Download Full-text

The effect of postnatal age on L -2-chloropropionic acid-induced cerebellar granule cell necrosis in the rat

Archives of Toxicology ◽

10.1007/s002040000194 ◽

2001 ◽

Vol 74 (12) ◽

pp. 783-788 ◽

Author(s):

Edward A. Lock ◽

Andrew Gyte ◽

Stephen Duffell ◽

Ian Wyatt

Keyword(s):

Granule Cell ◽

Cerebellar Granule Cell ◽

Cell Necrosis ◽

Cerebellar Granule ◽

Cerebellar Granule Cell Necrosis

Download Full-text

Calpain Activation and Not Oxidative Damage Mediatesl-2-Chloropropionic Acid-Induced Cerebellar Granule Cell Necrosis

Toxicology and Applied Pharmacology ◽

10.1006/taap.1996.7940 ◽

1997 ◽

Vol 142 (2) ◽

pp. 248-255 ◽

Author(s):

P.S. Widdowson ◽

A. Gyte ◽

R. Upton ◽

J. Foster ◽

C.T. Coutts ◽

...

Keyword(s):

Oxidative Damage ◽

Granule Cell ◽

Cerebellar Granule Cell ◽

Cell Necrosis ◽

Cerebellar Granule ◽

Calpain Activation ◽

Cerebellar Granule Cell Necrosis

Download Full-text

Restoration in vitro of the normal timing of exiting of cerebellar granule cell precursors from the cell cycle by Sonic hedgehog

Neuroscience Research ◽

10.1016/s0168-0102(00)81629-6 ◽

2000 ◽

Vol 38 ◽

pp. S130

Author(s):

Y Ishizaki

Keyword(s):

Sonic Hedgehog ◽

Granule Cell ◽

Cerebellar Granule Cell ◽

Cerebellar Granule ◽

Granule Cell Precursors

Download Full-text