Mortality and morbidity in long-term surviving patients treated with chemotherapy with or without irradiation for small-cell lung cancer

Lung Cancer ◽  
1987 ◽  
Vol 3 (1) ◽  
pp. 54-55
1994 ◽  
Vol 80 (2) ◽  
pp. 151-156
Author(s):  
Elvira D'Alessandro ◽  
Maria Luisa Lo Re ◽  
Roberto Crisci ◽  
Claudio Ligas ◽  
Giorgio Furio Coloni

Non-small cell lung cancer (NSCLC) shows a complex cytogenetic heterogeneity and up to now no particular chromosomal aberration seems to characterize its malignant evolution. We therefore performed cytogenetic analyses of 20 primary NSCLC, 8 adenocarcinomas and 12 squamous cell carcinomas on direct preparations or short-term cultures. Only 1 case was analyzed after long-term culture. Results were obtained from 11 samples and clonal rearrangements were found in 3 cases, a diploid and a near-triploid clone with several aberrations such as i (9q), rob (14; 15) and rob (21; 21) in 1 case, a near-triploid clone in 1 case, and Y chromosome loss in 1 case. Other aberrations found were sporadic, but + 7 aneuploidy and translocations involving 1p were detected in 2 and 3 samples respectively. Although to date it has been very difficult to recognize primary changes in NSCLC, nevertheless a literature review and our results indicate that i(9q) and robertsonian translocations are relevant findings.


2006 ◽  
Vol 106 (5) ◽  
pp. 550-553 ◽  
Author(s):  
Y.A. Karamustafaoglu ◽  
G. Haciibrahimoglu ◽  
M. Fazlioglu ◽  
A. Olcmen ◽  
C.A. Kutlu ◽  
...  

Cancer ◽  
1982 ◽  
Vol 49 (2) ◽  
pp. 221-223 ◽  
Author(s):  
Edward C. Bradley ◽  
Geraldine P. Schechter ◽  
Mary J. Matthews ◽  
Jacqueline Whang-Peng ◽  
Martin H. Cohen ◽  
...  

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