Lung Cancer Patients
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2022 ◽  
Vol 15 (1) ◽  
pp. 101254
Si-Yang Maggie Liu ◽  
Hao Sun ◽  
Jia-Ying Zhou ◽  
Jia-Tao Zhang ◽  
Kai Yin ◽  

Shivani Jain ◽  
Vinod Joshi ◽  
Aashish Singh ◽  
Shubhra Jain ◽  
Saurabh Godika

Background: At our tertiary care hospital we receive a large number of lung cancer patients, mostly in poor general conditions; hence we decided to conduct this study to perform a comprehensive evaluation of the demographic profile of lung cancer at our institute, Institute of respiratory disease (IRD), Swai Man Singh Medical (SMS) College and Hospital Methods: This study was conducted at Institute of Respiratory Disease (IRD), Swai Mansingh (SMS) Medical Collage, Jaipur after taking necessary permission from Ethical Committee and Research Review Board of SMS Medical College,   Jaipur. Results: Mean age of the patients was 61.4±6.8; it was higher in male 61.60±6.7. Out of 105 patients majority of patients were (85.7 %) male. Most of the patients (72.4%) were belonged to rural area .In context of education it is indicated that about 36 % of the patients were primary school educated while 25.7 to 26.7 constituted high & middle school respectively followed by graduate & illiterates (5.7 %) respectively Conclusion: We concluded that lung cancer was commonly found in elderly male belong to low socio-economic status Keywords: Lung cancer, Male, SES

Stanisław Orzechowski ◽  
Maciej Gnass ◽  
Damian Czyżewski ◽  
Jacek Wojtacha ◽  
Barbara Sudoł ◽  

Immunotherapy ◽  
2021 ◽  
Cinzia Baldessari ◽  
Annarita Pecchi ◽  
Raffaella Marcheselli ◽  
Giorgia Guaitoli ◽  
Riccardo Bonacini ◽  

Background: Immunotherapy changed the landscape of non-small cell lung cancer (NSCLC). Efforts were made to implement its action. This study aims to describe body composition, nutritional and inflammatory status in NSCLC patients treated by first-line immunotherapy, their correlation, variation and impact. Patients and methods: We retrospectively analyzed 44 consecutive patients who received pembrolizumab treatment. Results: During the therapy, inflammation and visceral fat increased, whereas muscle and subcutaneous fat decreased. Parameters related to inflammation had an interesting prognostic impact. High numbers of white blood cells remained significantly correlated with a high risk of death in multivariate model. Conclusion: For the best treatment choice, a combination of clinical and biological factors will be most likely be necessary. Prospective and larger studies with a multidimensional approach are needed.

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Yanhua Jiao ◽  
Liling Guo ◽  
Linqian Wu ◽  
Tongshan Hu

Objective. To analyze the relationship between hypercoagulable state and circulating tumor cells (CTCs) in peripheral blood, pathological characteristics, and prognosis of lung cancer patients. Method. A total of 148 patients with primary lung cancer diagnosed and treated in our hospital from January 2017 to January 2019 were selected as the research objects. According to the CTC test results, the patients were divided into CTC-positive group and CTC-negative group. Also, the coagulation index of patients was tested. According to the blood coagulation index test results, patients were divided into hypercoagulable group and non-hypercoagulable group. The relationship between hypercoagulable state and pathological characteristics of lung cancer patients was analyzed by single factor analysis and multiple logistic regression model. Kaplan–Meier survival curve was applied to analyze the relationship between hypercoagulable state and the prognosis of lung cancer patients. Results. The platelets (PLTs), fibrinogen (FIB), D-dimer (D-D), and prothrombin time (PT) in CTC-positive group were significantly higher than those in CTC-negative group. There was no significant relationship between the patient’s gender, smoking history, pathological type, and the hypercoagulable state of the patients. The proportion of patients aged 60 years or older, with TMN stage III or IV and lymph node metastasis, in the hypercoagulable group was significantly higher than that in the non-hypercoagulable group. Logistic regression analysis showed that there was an independent relationship between the patient’s age, lymph node metastasis, and hypercoagulable state. As of January 2020, among the 148 patients with lung cancer follow-up, 5 patients were lost and 52 died. The median survival time of patients in the hypercoagulable group was 82 weeks, which was significantly lower than the 104 weeks in the nonhypercoagulable group. Conclusion. There is a certain relationship between hypercoagulable state and CTC positive in lung cancer patients. There is an independent relationship between the patient’s age, lymph node metastasis, and the hypercoagulable state. The median survival time of patients in the hypercoagulable group was significantly lower than that in the non-hypercoagulable group.

2021 ◽  
Vol 14 (11) ◽  
pp. 1067
Katarzyna Beata Skórska ◽  
Sylwia Płaczkowska ◽  
Anna Prescha ◽  
Irena Porębska ◽  
Monika Kosacka ◽  

Background: Redox status disturbances are known during carcinogenesis and may have influence on patients’ survival. However, the prediction of mortality in lung cancer patients based on serum total SOD activity, and concentrations of its isoforms, has not been studied to date. This prospective cohort study has following aims: (1) to evaluate the disturbances in serum SOD activity and SOD1/2 concentrations; (2) to assess the implications of these alterations with regard to biochemical variables and clinical data, and (3) to investigate the association between serum SOD activity, SOD1/2 concentrations, and all-cause mortality in lung cancer patients. Methods: Serum total SOD activity and SOD1, SOD2, albumin, CRP, and ceruloplasmin concentrations were determined in lung cancer patients (n = 190) and control subjects (n = 52). Additionally, patients were characterized in terms of biochemical, clinical, and sociodemographic data. Multiple Cox regression models were used to estimate the association between all-cause death and SOD-related parameters. Results: All-cause mortality in lung cancer was positively associated with serum SOD1 and SOD2 concentrations. Clinical stage III and IV disease was the strongest predictor. The utility of the evaluated parameters in predicting overall survival was demonstrated only for SOD1. Conclusions: Serum SOD1 and SOD2 concentrations were shown to positively affect all-cause mortality in lung cancer patients, but SOD1 seems to be a better predictor than SOD2.

2021 ◽  
Vol 28 (6) ◽  
pp. 4247-4255
Goulnar Kasymjanova ◽  
Aksa Anwar ◽  
Victor Cohen ◽  
Khalil Sultanem ◽  
Carmela Pepe ◽  

The large burden of COVID-19 on health care systems worldwide has raised concerns among medical oncologists about the impact of COVID-19 on the diagnosis and treatment of lung cancer patients. In this retrospective cohort study, we investigated the impact of COVID-19 on lung cancer diagnosis and treatment before and during the COVID-19 era. New lung cancer diagnoses decreased by 34.7% during the pandemic with slightly more advanced stages of disease, there was a significant increase in the utilization of radiosurgery as the first definitive treatment, and a decrease in both systemic treatment as well as surgery compared to the pre-COVID-19 era. There was no significant delay in starting chemotherapy and radiation treatment during the pandemic compared to pre-COVID-19 time. However, we observed a delay to lung cancer surgery during the pandemic time. COVID-19 seems to have had a major impact at our lung cancer center on the diagnoses and treatment patterns of lung cancer patients. Many oncologists fear that they will see an increase in newly diagnosed lung cancer patients in the coming year. This study is still ongoing and further data will be collected and analyzed to better understand the total impact of the COVID-19 pandemic on our lung cancer patient population.

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Wenwen Zhou ◽  
Yanhong Yang ◽  
Zhenzhen Wang ◽  
Yan Liu ◽  
Moslem Lari Najafi

Lung cancer is a lethal disease, and early diagnosis with the aid of biomarkers such as HSP90α protein can certainly assist the doctors to start treatment of patient at the earliest and can save their lives. To analyse the diagnostic value of HSP90α expression in lung cancer patients by collecting data of patients through IoT devices to avoid delay in treatments, a study has been presented in this paper where the significance of HSP90α biomarker is highlighted in early diagnosis of patients suffering from lung cancer. The second objective of the research study is to examine the correlation between the appearance level of HSP90α biomarker and the clinicopathological features of lung cancer. It is also evaluated whether the changes in HSP90α index are indicative or noteworthy before and after surgery of lung cancer patients. An observatory study of 78 patients with lung cancer in Qinhuangdao Hospital is presented in this paper where the samples were collected from June 2018 to March 2020. Their data were collected through IoT devices used in the latest healthcare facilities of the hospital. The ELISA method was utilized to identify the level of plasma HSP90 and to analyse HSP90 levels between the lung cancer group and healthy group of people. The relationship between HSP90 and the clinical pathological features of 78 patients suffering from lung cancer was analysed. An electrochemical luminescence method was used to detect CEA, NSE, SCC, and CYFRA21-1 levels. ROC curve and box plots were used to determine the analytic value of HSP90 and other biomarkers used in lung cancer diagnosis. Forty-two patients with moderate to early stage lung cancer with surgical correction were selected, and paired sample T test was used to analyse HSP90 levels before and after surgery. The plasma HSP90 level of lung cancer patients was quite higher as compared to the group of healthy people as per the values depicted in the research study. Second, HSP90 levels are substantially higher in pathologic type, differentiation degree, stage, and the existence of the lung, liver, and bone metastases ( P  < 0.05). The level of HSP90 expression was largely impacted by a few factors such as sex, age, smoking, and tumour location ( P  > 0.05). The ROC value for HSP90 was 0.599, while the area under the curve of HSP90 combined with other four tumour markers was 0.915 in the presented case study, indicating the presence of lung cancer. Patients with lung cancer had statistically significant differences in HSP90 expression levels before and after surgery ( P  < 0.05). It is concluded that the expression level of plasma HSP90α in lung cancer patients increases remarkably; therefore, HSP90 can be used to monitor presence of lung cancer before and after surgery in the patients.

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