P3458 Inflammatory response to coronary artery bypass surgery: does the Heme-Oxygenase-1 gene microsatellite polymorphism play a role?

2003 ◽  
Vol 24 (5) ◽  
pp. 669
Author(s):  
P LI
2010 ◽  
Vol 33 (3) ◽  
pp. 131-138 ◽  
Author(s):  
Thomas Rimmelé ◽  
Ramesh Venkataraman ◽  
Nicholas J. Madden ◽  
Michele M. Elder ◽  
Lawrence M. Wei ◽  
...  

2011 ◽  
Vol 10 (02) ◽  
pp. 80-84
Author(s):  
Zhong-Kai Wu ◽  
Jari Laurikka ◽  
Erkki Pehkonen ◽  
Seppo Kaukinen ◽  
Liisa Kaukinen ◽  
...  

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
A. S. Golovkin ◽  
V. G. Matveeva ◽  
I. V. Kudryavtsev ◽  
M. N. Chernova ◽  
Y. V. Bayrakova ◽  
...  

Hypercytokinemia plays a key role in the pathogenesis of systemic inflammatory response syndrome (SIRS). Monocytes are the main source of cytokines in the early inflammatory phase. Simultaneous stimulation of toll-like receptors (TLRs) and triggering receptor expressed on myeloid cells (TREM-1) activating receptor on monocytes results in the amplification of the inflammatory signal and multiple increase in proinflammatory cytokine production. The dynamics of those receptors expression on monocyte surface of patients with uncomplicated SIRS course followed coronary artery bypass surgery (CABG) was studied. The increase in TLR2 and TREM-1 expression on the first day after CABG induces proinflammatory and amplification potentials of monocytes in that period. The decrease in TLR2 surface expression on the seventh day compared to the preoperative values can be regarded as a mechanism limiting inflammatory response. The highest level of TLR2, TLR4, and TREM-1 surface expression was observed in CD14hiCD16+ monocyte subpopulation, confirming its proinflammatory profile.


2006 ◽  
Vol 40 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Obaid Aljassim ◽  
Martin Karlsson ◽  
Lars Wiklund ◽  
Anders Jeppsson ◽  
Per Olsson ◽  
...  

2004 ◽  
Vol 32 (Supplement) ◽  
pp. A148 ◽  
Author(s):  
Ramesh Venkataraman ◽  
Melinda Carter ◽  
Michele Elder ◽  
Malik Rahim ◽  
John Kellum ◽  
...  

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