Dorsolateral prefrontal cortex activation during automatic auditory duration-mismatch processing in humans: a positron emission tomography study

2001 ◽  
Vol 308 (2) ◽  
pp. 119-122 ◽  
Author(s):  
Alexandra Dittmann-Balçar ◽  
Markus Jüptner ◽  
Walter Jentzen ◽  
Ulrich Schall
2000 ◽  
Vol 42 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Yasuyuki Gondo ◽  
Yoshiko Shimonaka ◽  
Michio Senda ◽  
Masahiro Mishina ◽  
Hinako Toyama

1998 ◽  
Vol 172 (4) ◽  
pp. 316-323 ◽  
Author(s):  
Sean A. Spence ◽  
Steven R. Hirsch ◽  
David J. Brooks ◽  
Paul M. Grasby

BackgroundHypo-activation of the left dorsolateral prefrontal cortex is inconsistently found in neuroimaging studies of schizophrenia. As the left dorsolateral prefrontal cortex is involved in the generation of action, disordered function in this region may be implicated in schizophrenic symptomatology.MethodWe used H215O positron emission tomography to study dorsolateral prefrontal cortical function in men with schizophrenia (n=13) and male control subjects (n=6) performing joystick movements on two occasions, 4–6 weeks apart. The patients were initially in relapse. To clarify dorsolateral prefrontal cortical function we also scanned another group of control subjects (n=5) performing mouth movements.ResultsThe control subjects performing hand or mouth movements activated the left dorsolateral prefrontal cortex to a maximum when the movements were self-selected. The men with relapsed schizophrenia exhibited left dorsolateral prefrontal cortical hypo-activation, which remitted with symptomatic improvement.ConclusionsHypofrontality in these patients is a dynamic phenomenon across time, possibly related to current symptomatology. The most appropriate question about the presence of hypofrontality in schizophrenia may be when, rather than whether, it will occur.


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