Regional distribution of parkinsonism-preventing endogenous tetrahydroisoquinoline derivatives and an endogenous parkinsonism-preventing substance-synthesizing enzyme in monkey brain

1999 ◽  
Vol 276 (1) ◽  
pp. 68-70 ◽  
Author(s):  
Takahiro Yamakawa ◽  
Yaichiro Kotake ◽  
Morioki Fujitani ◽  
Hideaki Shintani ◽  
Yukiko Makino ◽  
...  
1976 ◽  
Vol 106 (1) ◽  
pp. 189-197 ◽  
Author(s):  
Rabi Simantov ◽  
Michael J. Kuhar ◽  
Gavril W. Pasternak ◽  
Solomon H. Snyder

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Örjan Lindhe ◽  
Per Almqvist ◽  
Matts Kågedal ◽  
Sven-Åke Gustafsson ◽  
Mats Bergström ◽  
...  

Zolmitriptan is a serotonin 5-HT1B/1D receptor agonist that is an effective and well-tolerated drug for migraine treatment. In a human positron emission tomography study, [11C]zolmitriptan crossed the blood-brain barrier but no clear pattern of regional uptake was discernable. The objective of this study was to map the binding of [11C]zolmitriptan in Rhesus monkey brain using whole hemisphere in vitro autoradiography with [11C]zolmitriptan as a radioligand. In saturation studies, [11C]zolmitriptan showed specific (90%) binding to a population of high-affinity binding sites (Kd 0.95–5.06 nM). There was regional distribution of binding sites with the highest density in the ventral pallidum, followed by the external globus pallidus, substantia nigra, visual cortex, and nucleus accumbens. In competitive binding studies with 5-HT1 receptor antagonists, [11C]zolmitriptan binding was blocked by selective 5-HT1B and 5-HT1D ligands in all target areas. There was no appreciable change in binding with the addition of a 5-HT1A receptor antagonist.


1962 ◽  
Vol 38 ◽  
pp. 48-48 ◽  
Author(s):  
M. Mansoor ◽  
G. D. Kalyankar ◽  
G. P. Talwar

1979 ◽  
Vol 4 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Kiyoshi Kataoka ◽  
Noboru Mizuno ◽  
Lawrence A. Frohman

1978 ◽  
Vol 159 (1) ◽  
pp. 228-233 ◽  
Author(s):  
Shigeru Matsukura ◽  
Hiroki Yoshimi ◽  
Satoru Sueoka ◽  
Kiyoshi Kataoka ◽  
Takuo Ono ◽  
...  

2006 ◽  
Vol 1104 (1) ◽  
pp. 175-182 ◽  
Author(s):  
Diana Radu ◽  
Birgitta Tomkinson ◽  
Olof Zachrisson ◽  
Günther Weber ◽  
Jacqueline de Belleroche ◽  
...  

1974 ◽  
Vol 66 (3) ◽  
pp. 541-546 ◽  
Author(s):  
Henry I. Yamamura ◽  
Michael J. Kuhar ◽  
David Greenberg ◽  
Solomon H. Snyder

1986 ◽  
Vol 390 (2) ◽  
pp. 302-308 ◽  
Author(s):  
J BACHEVALIER ◽  
L UNGERLEIDER ◽  
J BLANCHEONEILL ◽  
D FRIEDMAN

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