The role of environmental familiarization in novel-object preference

2000 ◽  
Vol 50 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Joyce Besheer ◽  
Rick A Bevins
Keyword(s):  
Novel Object ◽  
Object Preference

scholarly journals Electroacupuncture reduces scopolamine-induced amnesia via mediating the miR-210/SIN3A and miR-183/SIN3A signaling pathway

2020 ◽  
Author(s):  
Fan Ye ◽  
Shiming Tian ◽  
Huimin Hu ◽  
Zhengwen Yu
Keyword(s):  
Object Recognition ◽  
Treatment Efficacy ◽  
Memory Function ◽  
Inhibitory Effect ◽  
Luciferase Assay ◽  
Novel Object Recognition ◽  
Quantitative Real Time Pcr ◽  
Novel Object ◽  
Underlying Mechanisms

Abstract Background: The expression of SIN3A is closely correlated with electroacupuncture (EA) treatment efficacy of scopolamine-induced amnesia (SIA), but its underlying mechanisms remain to be further explored. Methods: Quantitative real-time PCR was performed to analyze the expression of candidate microRNAs (miRNAs) and SIN3A mRNA in a rat model of SIA. Western blot was carried out to evaluate the differential expression of SIN3A proteins under different circumstances. Luciferase assay was used to explore the inhibitory role of certain miRNAs in SIN3A expression. A novel object recognition (NOR) test was performed to assess the memory function of SIA rats undergoing EA treatment. Immunohistochemistry was carried out to evaluate the expression of SIN3A in the hippocampus of SIA rats. Results: Rno-miR-183-5p, rno-miR-34c-3p and rno-miR-210-3p were significantly up-regulated in SIA rats treated with EA. In addition, rno-miR-183-5p and rno-miR-210-3p exerted an inhibitory effect on SIN3A expression. EA treatment of SIA rats effectively restored the dysregulated expression of rno-miR-183-5p, rno-miR-210-3p and SIN3A. EA treatment also promoted the inhibited expression of neuronal IEGs including Arc, Egr1, Homer1 and Narp in the hippocampus of SIA rats. Accordingly, the NOR test also confirmed the effect of EA treatment on the improvement of memory in SIA rats.Conclusion: In summary, the findings of this study demonstrated that scopolamine-induced amnesia was associated with downregulated expression of miR-210/miR-183 and upregulated expression of SIN3A. Furthermore, treatment with EA alleviated scopolamine-induced amnesia in rats and was associated with upregulated expression of miR-210/miR-183 and downregulated expression of SIN3A.

scholarly journals Electroacupuncture reduces scopolamine-induced amnesia via mediating the miR-210/SIN3A and miR-183/SIN3A signaling pathway

2020 ◽  
Author(s):  
Fan Ye ◽  
Shiming Tian ◽  
Huimin Hu ◽  
Zhengwen Yu
Keyword(s):  
Object Recognition ◽  
Treatment Efficacy ◽  
Memory Function ◽  
Inhibitory Effect ◽  
Luciferase Assay ◽  
Novel Object Recognition ◽  
Quantitative Real Time Pcr ◽  
Novel Object ◽  
Underlying Mechanisms

Abstract Background: The expression of SIN3A is closely correlated with electroacupuncture (EA) treatment efficacy of scopolamine-induced amnesia (SIA), but its underlying mechanisms remain to be further explored. Methods: Quantitative real-time PCR was performed to analyze the expression of candidate microRNAs (miRNAs) and SIN3A mRNA in a rat model of SIA. Western blot was carried out to evaluate the differential expression of SIN3A proteins under different circumstances. Luciferase assay was used to explore the inhibitory role of certain miRNAs in SIN3A expression. A novel object recognition (NOR) test was performed to assess the memory function of SIA rats undergoing EA treatment. Immunohistochemistry was carried out to evaluate the expression of SIN3A in the hippocampus of SIA rats. Results: Rno-miR-183-5p, rno-miR-34c-3p and rno-miR-210-3p were significantly up-regulated in SIA rats treated with EA. In addition, rno-miR-183-5p and rno-miR-210-3p exerted an inhibitory effect on SIN3A expression. EA treatment of SIA rats effectively restored the dysregulated expression of rno-miR-183-5p, rno-miR-210-3p and SIN3A. EA treatment also promoted the inhibited expression of neuronal IEGs including Arc, Egr1, Homer1 and Narp in the hippocampus of SIA rats. Accordingly, the NOR test also confirmed the effect of EA treatment on the improvement of memory in SIA rats. Conclusion: In summary, the findings of this study demonstrated that scopolamine-induced amnesia was associated with downregulated expression of miR-210/miR-183 and upregulated expression of SIN3A. Furthermore, treatment with EA alleviated scopolamine-induced amnesia in rats and was associated with upregulated expression of miR-210/miR-183 and downregulated expression of SIN3A.

Assessment of Dopamine Involvement in Novel-Object Preference

1999 ◽  
Author(s):  
Joyce Besheer ◽  
Cho-Khan Outten ◽  
Rick A. Bevins
Keyword(s):  
Novel Object ◽  
Object Preference

scholarly journals The role of timing and prototypical causality on how preschoolers fast-map novel verb meanings

2016 ◽  
Vol 37 (2) ◽  
pp. 186-204 ◽  
Author(s):  
Kirsten Abbot-Smith ◽  
Mutsumi Imai ◽  
Samantha Durrant ◽  
Erika Nurmsoo
Keyword(s):  
Young Children ◽  
The Novel ◽  
Visual Salience ◽  
Verb Learning ◽  
Improve Performance ◽  
Novel Object ◽  
Relative Ease ◽  
English Speaking ◽  
Novel Words

In controlled contexts, young children find it more difficult to learn novel words for actions than words for objects: Imai et al. found that English-speaking three-year-olds mistakenly choose a novel object as a referent for a novel verb about 42% of the time despite hearing the verb in a transitive sentence. The current two studies investigated whether English three- and five-year-old children would find resultative actions easier (since they are prototypically causative) than the non-resultative, durative event types used in Imai et al.’s studies. The reverse was true. Furthermore, if the novel verbs were taught on completion of the action, this did not improve performance, which contrasts with previous findings. The resultative actions in the two studies reported here were punctual, change-of-location events which may be less visually salient than the non-resulative, durative actions. Visual salience may play a greater role than does degree of action causality in the relative ease of verb learning even at three years.

The role of apelin-13 in novel object recognition memory

Peptides ◽  
2014 ◽  
Vol 62 ◽  
pp. 155-158 ◽  
Author(s):  
Ren-wen Han ◽  
Hong-jiao Xu ◽  
Rui-san Zhang ◽  
Rui Wang
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Object Recognition Memory

scholarly journals The role of comparison in preschoolers’ novel object categorization

2010 ◽  
Vol 107 (3) ◽  
pp. 280-290 ◽  
Author(s):  
Susan A. Graham ◽  
Laura L. Namy ◽  
Dedre Gentner ◽  
Kristinn Meagher
Keyword(s):  
Object Categorization ◽  
Novel Object
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