Adverse facial edema associated with off-label use of recombinant human bone morphogenetic protein–2 in cranial reconstruction for craniosynostosis: case report

2009 ◽  
Vol 2009 ◽  
pp. 249-250
Author(s):  
P. Klimo
Keyword(s):  
Case Report ◽  
Bone Morphogenetic Protein ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Off Label Use ◽  
Off Label ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Facial Edema ◽  
Recombinant Human Bone

Adverse facial edema associated with off-label use of recombinant human bone morphogenetic protein–2 in cranial reconstruction for craniosynostosis

2008 ◽  
Vol 1 (3) ◽  
pp. 255-257 ◽  
Author(s):  
M. Mohsin Shah ◽  
Matthew D. Smyth ◽  
Albert S. Woo
Keyword(s):  
Bone Morphogenetic Protein ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Off Label Use ◽  
Local Inflammatory Response ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Facial Edema ◽  
Recombinant Human Bone

✓The authors present a case of scalp and facial edema following craniofacial reconstruction for metopic craniosynostosis in which recombinant human bone morphogenetic protein–2 (rhBMP-2) was used to treat cranial defects related to the frontoorbital reconstruction. The extent of swelling, the onset, and duration were unusual for such cases and suggested a possible role of rhBMP-2 in inducing a local inflammatory response. The edema rapidly resolved after the patient underwent surgery to remove the rhBMP-2 implants.

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