scholarly journals CARDIAC OUTPUT IS ALTERED IN FETUSES WITH HYPOPLASTIC LEFT HEART SYNDROME AND TRANSPOSITION OF THE GREAT ARTERIES COMPARED TO NORMAL CONTROLS; LESSONS LEARNED FROM FETAL ECHOCARDIOGRAM

2016 ◽  
Vol 67 (13) ◽  
pp. 959
Author(s):  
Tarek Alsaied ◽  
Eileen King ◽  
Stephanie Tseng ◽  
Allison Divanovic ◽  
Eunice Hahn ◽  
...  
2016 ◽  
Vol 2016 ◽  
pp. 1-9
Author(s):  
Yan Jiang ◽  
Yali Xu ◽  
Jinliang Tang ◽  
Hongmei Xia

Aims. To detect anatomical and intrinsic histopathological features of the ascending aorta and left ventricular (LV) myocardium and evaluate right ventricular (RV) function in fetuses with hypoplastic left heart syndrome (HLHS).Methods. Twenty-five fetuses diagnosed with HLHS were followed up in the antenatal and postpartum periods. 12 necropsy heart specimens were analyzed for morphological and histological changes.Results. Prenatal echocardiography and pathologic anatomy displayed the typical characteristics of HLHS as a severe underdevelopment of the LV in the form of mitral stenosis or atresia or as aortic atresia or stenosis, with a decreased ratio of aortic diameter to pulmonary artery diameter (median of 0.49 with a range of 0.24 to 0.69,p≤0.001) and a higher ratio of RV diameter to LV diameter (median of 2.44 with a range of 1.33 to 6.25,p≤0.001). The RV volume, stroke volume, and cardiac output in HLHS fetuses were increased compared with the gestational age-matched normal controls (p<0.01). Histological changes in the 12 HLHS specimens included LV myocardial fibrosis, aortic elastic fragmentation, and fibrosis.Conclusions. In addition to severe anatomical deformity, distinct histological abnormalities in the LV myocardium and aortic wall were identified in the fetuses with HLHS. RV function damage may be potentially exists.


Author(s):  
Ali Jalali ◽  
C. Nataraj ◽  
Gerard F. Jones ◽  
Daniel J. Licht

Hypoplastic left heart syndrome (HLHS) is a congenital heart defect (CHD) in which left side of the heart is severely underdeveloped. To better understand this unique physiology, a computational model of the hypoplastic heart was constructed on the basis of compartmental analysis. Lumped parameter model of HLHS is developed based on the electrical circuit analogy. Model is made up of three parts: hypoplastic heart, pulmonary circulation and systemic circulation. Plots of blood pressure and flow for various parts of body show great match between predicted values and what we expected for the case of HLHS babies. Influence of patent ductus arteriosus (PDA) and ASD resistances on cardiac output and pulmonary to systemic flow was also studied. Results show that by increasing the PDA resistance causes more flow to pulmonary compartments and so the ratio increases. Blood flow increases by decreasing of pulmonary artery resistant. Increasing the PDA resistance causes decrease the cardiac output because of more resistance against blood occurs. Saturation increases by decreasing of pulmonary artery resistant.


2020 ◽  
Vol 37 (S 02) ◽  
pp. S54-S56
Author(s):  
Italo Francesco Gatelli ◽  
Ottavio Vitelli ◽  
Gaia Chiesa ◽  
Francesca De Rienzo ◽  
Stefano Martinelli

Objective This study aimed to describe the first two cases of electrical cardiometry applied to newborn with hypoplastic left heart syndrome for hemodynamical assessment in the first days of life before surgical correction and see if this can help decision making process in these patients. Study Design We describe two case series of two full-term newborn with hypoplastic left heart syndrome in the Neonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano Niguarda, between December 2019 and January 2020. Results Case 1 was persistently hemodynamically stable with prostaglandin E1 infusion at 0.01 mcg/kg/min, showing good capillary refill time, good diuresis, no difference between pre- and postductal values of oxygen saturation or blood pressure. Electrical cardiometry monitoring constantly showed cardiac output values higher than 300 mL/kg/min. Case 2 showed poor clinical condition needing prostaglandin E1 infusion up to 0.05 mcg/kg/min, intubation and septostomy associated with low cardiac output around 190 mL/kg/min. Once cardiac output has begun to rise and reached values constantly over 300 mL/kg/min, clinical condition improved with amelioration in oxygen saturation, diuresis, blood pressure, and blood gas analysis values. She was then extubated and finally clinically stable until surgery with minimal infusion of prostaglandin E1 at 0.01 mcg/kg/min. Conclusion This case highlights how hemodynamic information provided by electrical cardiometry can be used to supplement the combined data from all monitors and the clinical situation to guide therapy in these newborns waiting surgery. Key Points


Sign in / Sign up

Export Citation Format

Share Document