P1956 In vitro activity of amphotericin B and anidulafungin against Candida albicans biofilms

ABSTRACT Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida albicans biofilms are recalcitrant to treatment with conventional antifungal therapies. Here we report on the activity of caspofungin, a new semisynthetic echinocandin, against C. albicans biofilms. Caspofungin displayed potent in vitro activity against sessile C. albicans cells within biofilms, with MICs at which 50% of the sessile cells were inhibited well within the drug's therapeutic range. Scanning electron microscopy and confocal scanning laser microscopy were used to visualize the effects of caspofungin on preformed C. albicans biofilms, and the results indicated that caspofungin affected the cellular morphology and the metabolic status of cells within the biofilms. The coating of biomaterials with caspofungin had an inhibitory effect on subsequent biofilm development by C. albicans. Together these findings indicate that caspofungin displays potent activity against C. albicans biofilms in vitro and merits further investigation for the treatment of biofilm-associated infections.

Download Full-text

In vitro activity of eugenol against Candida albicans biofilms

Mycopathologia ◽

10.1007/s11046-007-0097-2 ◽

2007 ◽

Vol 163 (3) ◽

pp. 137-143 ◽

Cited By ~ 71

Author(s):

Miao He ◽

Minquan Du ◽

Mingwen Fan ◽

Zhuan Bian

Keyword(s):

Candida Albicans ◽

Vitro Activity ◽

In Vitro Activity ◽

Candida Albicans Biofilms

Download Full-text

In vitro activity of a new echinocandin, LY303366, compared with those of amphotericin B and fluconazole against clinical yeast isolates.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.41.5.1156 ◽

1997 ◽

Vol 41 (5) ◽

pp. 1156-1157 ◽

Cited By ~ 54

Author(s):

O Uzun ◽

S Kocagöz ◽

Y Cetinkaya ◽

S Arikan ◽

S Unal

Keyword(s):

Candida Albicans ◽

Amphotericin B ◽

Vitro Activity ◽

In Vitro Activity ◽

Broth Microdilution ◽

Microdilution Method ◽

Broth Microdilution Method

The in vitro activity of LY303366, a new echinocandin derivative, was evaluated with 191 yeast isolates by a broth microdilution method. The MICs at which 50% of the isolates were inhibited were 0.125 microg/ml for Candida albicans and C. tropicalis, 0.25 microg/ml for C. krusei, C. kefyr, and C. glabrata, and 2.0 microg/ml for C. parapsilosis.

Download Full-text

In Vitro Activity of a New Polyene, SPA-S-843, against Yeasts

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.42.11.3012 ◽

1998 ◽

Vol 42 (11) ◽

pp. 3012-3013 ◽

Cited By ~ 9

Author(s):

C. Rimaroli ◽

T. Bruzzese

Keyword(s):

Candida Albicans ◽

Amphotericin B ◽

Candida Tropicalis ◽

Candida Glabrata ◽

Fungicidal Activity ◽

Candida Krusei ◽

Water Soluble ◽

Vitro Activity ◽

In Vitro Activity

ABSTRACT The in vitro activity of a new water-soluble polyene, SPA-S-843, was evaluated against 116 strains of Candida,Cryptococcus, and Saccharomyces spp. and compared with that of amphotericin B. SPA-S-843 demonstrated better inhibitory activity against all of the yeasts examined and better fungicidal activity against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis than did amphotericin B.

Download Full-text