Design, synthesis and biological activity of novel non-amidine factor Xa inhibitors. Part 1: P1 structure–activity relationships of the substituted 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides

2002 ◽  
Vol 12 (12) ◽  
pp. 1651-1655 ◽  
Author(s):  
Zhaozhong J. Jia ◽  
Yanhong Wu ◽  
Wenrong Huang ◽  
Erick Goldman ◽  
Penglie Zhang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Substituted 1

Rational Design, Synthesis, and Structure−Activity Relationships of Novel Factor Xa Inhibitors:  (2-Substituted-4-amidinophenyl)pyruvic and -propionic Acids1

2003 ◽  
Vol 46 (10) ◽  
pp. 1845-1857 ◽  
Author(s):  
Kazuyuki Sagi ◽  
Tadakiyo Nakagawa ◽  
Masahiro Yamanashi ◽  
Shingo Makino ◽  
Mitsuo Takahashi ◽  
...  
Keyword(s):  
Rational Design ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity

Design, synthesis and structure–Activity relationships of benzoxazinone-Based factor Xa inhibitors

2003 ◽  
Vol 13 (3) ◽  
pp. 561-566 ◽  
Author(s):  
Wenrong Huang ◽  
Penglie Zhang ◽  
Jingmei F Zuckett ◽  
Lingyan Wang ◽  
John Woolfrey ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

2020 ◽  
Vol 44 (6) ◽  
pp. 2247-2255
Author(s):  
Qifan Zhou ◽  
Lina Jia ◽  
Fangyu Du ◽  
Xiaoyu Dong ◽  
Wanyu Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Activity Assay ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Enhancer Of Zeste

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining with in vitro biological activity assay and docking results.

Design, synthesis, and in vitro biological activity of benzimidazole based factor Xa inhibitors

2000 ◽  
Vol 10 (9) ◽  
pp. 963-966 ◽  
Author(s):  
Zuchun (Spring) Zhao ◽  
Damian O Arnaiz ◽  
Brian Griedel ◽  
Steven Sakata ◽  
Jerry L Dallas ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis
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