Introduction. The importance of understanding the biology of breast cancer is
increasing and the determination of certain phenotypic characteristics of
malignant cells, especially estrogen, progesterone and human epidermal growth
factor receptor 2 expression, became a standard evaluation procedure in
breast cancer patients, in order to provide prognostic information and best
therapeutic options. Material and methods. This study included a total of 206
patients, all treated and followed up in the Daily Chemotherapy Hospital of
the Health Center Vranje. Estrogen, progesterone and human epidermal growth
factor receptor 2 statuses were evaluated in all patients to assess their
potential impact on the progression-free and overall survival. Results.
Two-thirds of patients were diagnosed at the early stage of the disease.
Ductal carcinoma was the most common histological type. Patients with early
stage breast cancer, with hormone-receptor positive and human epidermal
growth factor receptor 2 negative tumors, had a significantly longer
progression-free survival. Conclusion. Hormone-receptor and human epidermal
growth factor receptor 2 status evaluation is still of great clinical
importance with a reliable prognostic value in breast cancer patients.