Antitumor agents. Part 186:11For part 185, see ref. [1]. Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors

1998 ◽  
Vol 6 (11) ◽  
pp. 2127-2131 ◽  
Author(s):  
Jian Guan ◽  
Xiao-Kang Zhu ◽  
Yoko Tachibana ◽  
Kenneth F. Bastow ◽  
Arnold Brossi ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Topoisomerase Ii Inhibitors ◽  
Synthesis And Biological Evaluation

Antitumor Agents. 185.†Synthesis and Biological Evaluation of Tridemethylthiocolchicine Analogues as Novel Topoisomerase II Inhibitors

1998 ◽  
Vol 41 (11) ◽  
pp. 1956-1961 ◽  
Author(s):  
Jian Guan ◽  
Xiao-Kang Zhu ◽  
Yoko Tachibana ◽  
Kenneth F. Bastow ◽  
Arnold Brossi ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Topoisomerase Ii Inhibitors ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of 4β-benzoxazolepodophyllotoxin hybrids as DNA topoisomerase-II targeting anticancer agents

RSC Advances ◽  
2015 ◽  
Vol 5 (118) ◽  
pp. 97314-97319 ◽  
Author(s):  
Suresh Paidakula ◽  
Shravankumar Kankala ◽  
Ranjith kumar Kankala ◽  
Bhasker Juluru ◽  
Sreekantha B. Jonnalagadda ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Dna Topoisomerase Ii ◽  
Human Tumour ◽  
Dna Topoisomerase ◽  
Tumour Cell Lines ◽  
Hoechst Staining ◽  
Synthesis And Biological Evaluation ◽  
Human Tumour Cell Lines

A series of new 4β-benzoxazolepodophyllotoxin compounds (9a–j) were prepared and screened for molecular modelling and cytotoxicity against various human tumour cell lines. Cell apoptosis evaluation was performed using Hoechst staining.

Synthesis and biological evaluation of histone deacetylase and DNA topoisomerase II-Targeted inhibitors

2018 ◽  
Vol 26 (8) ◽  
pp. 1920-1928 ◽  
Author(s):  
Mitsuaki Yamashita ◽  
Teruyuki Tahara ◽  
Shinya Hayakawa ◽  
Hironobu Matsumoto ◽  
Shun-ichi Wada ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Targeted Inhibitors ◽  
Synthesis And Biological Evaluation
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