Crystal structure of Aquifex aeolicus gene product Aq1627: a putative phosphoglucosamine mutase reveals a unique C-terminal end-to-end disulfide linkage

The crystal structure of Aq1627 protein from Aquifex aeolicus, a hyperthermophilic bacterium has been solved, which reveals a unique end-to-end disulfide linkage.

C-Peptide replacement therapy in type 1 diabetes: are we in the trough of disillusionment?

C-Peptide has been discussed as a missing component in therapy for people with Type 1 diabetes. Is momentum fading, or do technology models suggest that it is right on schedule?

Anticancer effects of novel resveratrol analogues on human ovarian cancer cells

We describe the molecular mechanisms of the action of novel trans-restricted analogues of resveratrol with enhanced anti-cancer properties.

Correction: Elucidating time-dependent changes in the urinary metabolome of renal transplant patients by a combined 1H NMR and GC-MS approach

Correction for ‘Elucidating time-dependent changes in the urinary metabolome of renal transplant patients by a combined 1H NMR and GC-MS approach’ by Kienana Muhrez et al., Mol. BioSyst., 2015, 11, 2493–2510.

A cross-platform metabolomics workflow for volume-restricted tissue samples: application to an animal model for polycystic kidney disease

Metabolic profiling provides an unbiased view of the physiological status of an organism as a “function” of the metabolic composition of a measured sample.

Computational investigation of the human SOD1 mutant, Cys146Arg, that directs familial amyotrophic lateral sclerosis

Molecular dynamics simulations along with the computational predictions used to assess the protein structural characterization as well as the conformational preferences of the monomeric native and mutant SOD1.

Real-time activity assays of β-lactamases in living bacterial cells: application to the inhibition of antibiotic-resistant E. coli strains

A UV-Vis approach is reported for activity assays and inhibition of β-lactamases in complex biological systems of living bacteria.