Synthesis and biological evaluation of histone deacetylase and DNA topoisomerase II-Targeted inhibitors

2018 ◽  
Vol 26 (8) ◽  
pp. 1920-1928 ◽  
Author(s):  
Mitsuaki Yamashita ◽  
Teruyuki Tahara ◽  
Shinya Hayakawa ◽  
Hironobu Matsumoto ◽  
Shun-ichi Wada ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Targeted Inhibitors ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of 4β-benzoxazolepodophyllotoxin hybrids as DNA topoisomerase-II targeting anticancer agents

RSC Advances ◽  
2015 ◽  
Vol 5 (118) ◽  
pp. 97314-97319 ◽  
Author(s):  
Suresh Paidakula ◽  
Shravankumar Kankala ◽  
Ranjith kumar Kankala ◽  
Bhasker Juluru ◽  
Sreekantha B. Jonnalagadda ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Dna Topoisomerase Ii ◽  
Human Tumour ◽  
Dna Topoisomerase ◽  
Tumour Cell Lines ◽  
Hoechst Staining ◽  
Synthesis And Biological Evaluation ◽  
Human Tumour Cell Lines

A series of new 4β-benzoxazolepodophyllotoxin compounds (9a–j) were prepared and screened for molecular modelling and cytotoxicity against various human tumour cell lines. Cell apoptosis evaluation was performed using Hoechst staining.

Histone deacetylase interacts directly with DNA topoisomerase II

10.1038/81671 ◽  
2000 ◽  
Vol 26 (3) ◽  
pp. 349-353 ◽  
Author(s):  
Shih-Chang Tsai ◽  
Nikola Valkov ◽  
Wen-Ming Yang ◽  
Jana Gump ◽  
Daniel Sullivan ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase

The in vivo distribution and dynamics of DNA topoisomerase II in Drosophila embryonic nuclei and chromosomes

1993 ◽  
Vol 51 ◽  
pp. 74-75
Author(s):  
Jason R. Swedlow ◽  
Neil Osheroff ◽  
Tim Karr ◽  
John W. Sedat ◽  
David A. Agard
Keyword(s):  
Topoisomerase Ii ◽  
Biochemical Characterization ◽  
Developmental Cycle ◽  
Dna Topoisomerase Ii ◽  
Chromosomal Distribution ◽  
Dna Topoisomerase ◽  
Ideal System ◽  
Dnase Treatment

DNA topoisomerase II is an ATP-dependent double-stranded DNA strand-passing enzyme that is necessary for full condensation of chromosomes and for complete segregation of sister chromatids at mitosis in vivo and in vitro. Biochemical characterization of chromosomes or nuclei after extraction with high-salt or detergents and DNAse treatment showed that topoisomerase II was a major component of this remnant, termed the chromosome scaffold. The scaffold has been hypothesized to be the structural backbone of the chromosome, so the localization of topoisomerase II to die scaffold suggested that the enzyme might play a structural role in the chromosome. However, topoisomerase II has not been studied in nuclei or chromosomes in vivo. We have monitored the chromosomal distribution of topoisomerase II in vivo during mitosis in the Drosophila embryo. This embryo forms a multi-nucleated syncytial blastoderm early in its developmental cycle. During this time, the embryonic nuclei synchronously progress through 13 mitotic cycles, so this is an ideal system to follow nuclear and chromosomal dynamics.

DNA Topoisomerase II Enzymes as Molecular Targets for Cancer Chemotherapy

2010 ◽  
Vol 999 (999) ◽  
pp. 1-14 ◽  
Author(s):  
K. Chikamori ◽  
A.G. Grozav ◽  
T. Kozuki ◽  
D. Grabowski ◽  
R. Ganapathi ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Topoisomerase Ii ◽  
Molecular Targets ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase

scholarly journals Multiple forms and cellular localization of Drosophila DNA topoisomerase II.

1986 ◽  
Vol 261 (17) ◽  
pp. 8063-8069
Author(s):  
R A Heller ◽  
E R Shelton ◽  
V Dietrich ◽  
S C Elgin ◽  
D L Brutlag
Keyword(s):  
Cellular Localization ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Multiple Forms ◽  
Dna Topoisomerase
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