Three year results of the double-blind randomized multicenter trial of mycophenolate mofetil in heart transplant patients

1999 ◽  
Vol 18 (1) ◽  
pp. 53 ◽  
Keyword(s):  
Mycophenolate Mofetil ◽  
Heart Transplant ◽  
Multicenter Trial ◽  
Double Blind ◽  
Transplant Patients

Mycophenolate Mofetil May Allow Cyclosporine and Steroid Sparing in De Novo Heart Transplant Patients

2007 ◽  
Vol 83 (5) ◽  
pp. 570-576 ◽  
Author(s):  
Iman M. Hamour ◽  
Haifa S. Lyster ◽  
Margaret M. Burke ◽  
Marlene L. Rose ◽  
Nicholas R. Banner
Keyword(s):  
Mycophenolate Mofetil ◽  
Heart Transplant ◽  
De Novo ◽  
Transplant Patients ◽  
Steroid Sparing

Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients

2002 ◽  
Vol 93 (2) ◽  
pp. 569-575 ◽  
Author(s):  
François Piquard ◽  
Ruddy Richard ◽  
Anne Charloux ◽  
Stephane Doutreleau ◽  
Thierry Hannedouche ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Renal Plasma Flow ◽  
Systemic Blood Pressure ◽  
Neutral Endopeptidase ◽  
Controlled Study ◽  
Sodium Reabsorption ◽  
Double Blind ◽  
Endothelin 1 ◽  
Transplant Patients ◽  
Nep Inhibition

We investigated the hemodynamic, renal, and hormonal responses to neutral endopeptidase (NEP) inhibition during a 6-h, double-blind, randomized, placebo-controlled study in seven chronic, stable heart transplant patients. Baseline characteristics were similar during both experiments, and no significant changes were observed after placebo. NEP inhibition increased circulating endothelin-1 (from 2.01 ± 0.1 to 2.90 ± 0.2 pmol/l; P < 0.01), atrial natriuretic peptide (ANP; from 21.5 ± 2.7 to 29.6 ± 3.7 pmol/l; P < 0.01), and the ANP second messenger cGMP. Noteworthy, systemic blood pressure did not increase. Renal plasma flow and glomerular filtration rate remained unmodified after NEP inhibition. Filtration fraction (33 ± 13%), diuresis (196 ± 62%), and natriuresis (315 ± 105%) increased significantly in relation to ANP and cGMP. A strong inverse relationship was observed between excreted cGMP and sodium reabsorption ( r = −0.71, P < 0.0001). Thus, despite significantly increasing endothelin-1, NEP inhibition did not adversely influence systemic or renal hemodynamics in transplant patients. ANP, possibly through a tubular action, enhances the natriuresis observed after NEP inhibition.

Everolimus But Not Mycophenolate Mofetil Therapy Is Associated With Soluble HLA-G Expression in Heart Transplant Patients

2009 ◽  
Vol 28 (11) ◽  
pp. 1193-1197 ◽  
Author(s):  
Rohit Sheshgiri ◽  
Finn Gustafsson ◽  
Jill Sheedy ◽  
Vivek Rao ◽  
Heather J. Ross ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Heart Transplant ◽  
Transplant Patients ◽  
Soluble Hla
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