Use of cDNA-Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions

1997 ◽  
pp. 171-188 ◽  
Author(s):  
Charles L. Crespi ◽  
Bruce W. Penman
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Potential Drug ◽  
Cytochrome P450 Enzymes ◽  
Human Cytochrome

scholarly journals Prediction of seriniquinone-drug interactions by in vitro inhibition of human cytochrome P450 enzymes

2020 ◽  
Vol 65 ◽  
pp. 104820
Author(s):  
Rodrigo Moreira da Silva ◽  
Daniel Blascke Carrão ◽  
Maísa Daniela Habenschus ◽  
Paula Christine Jimenez ◽  
Norberto Peporine Lopes ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Cytochrome P450 Enzymes ◽  
Human Cytochrome ◽  
In Vitro Inhibition

A Review of Drug Interactions With Psychiatric Medicines for the Pharmacy Practitioner

2007 ◽  
Vol 20 (4) ◽  
pp. 327-333 ◽  
Author(s):  
Eric C. Kutscher ◽  
Bruce Alexander
Keyword(s):  
Cytochrome P450 ◽  
General Population ◽  
Drug Interactions ◽  
Clinical Effect ◽  
Computer Software ◽  
Potential Drug ◽  
Cytochrome P450 Enzymes ◽  
Over The Counter ◽  
Software Programs

With thousands of potential drug interactions, it is next to impossible to remember them all, especially with many people on multiple prescriptions and over-the-counter medications. With the increasing use of psychiatric medicines in the general population, drug interactions may occur without recognition or warning. Pharmacy computer software programs provide help with identifying the majority of potential drug interactions, but these systems are only as good as the user who develops them. Some drug interactions are negligible, whereas others are quite significant. It is most important to remember drug interactions that may have a significant clinical effect. Approximately half of all medications prescribed today are affected by cytochrome P450 enzymes, but other interactions that involve various mechanisms can also be problematic. This review identifies drug interactions that may occur with the most frequently prescribed psychiatric medications and provides a review of selected interactions that may be clinically relevant for the pharmacist to review.

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