A Single Dose of Propofol at the End of Surgery for the Prevention of Emergence Agitation in Children Undergoing Strabismus Surgery during Sevoflurane Anesthesia

2008 ◽  
Vol 2008 ◽  
pp. 88
Author(s):  
S. Black
Keyword(s):  
Single Dose ◽  
Strabismus Surgery ◽  
Sevoflurane Anesthesia ◽  
Emergence Agitation

scholarly journals Comparison of the Effects of 0.03 and 0.05 mg/kg Midazolam with Placebo on Prevention of Emergence Agitation in Children Having Strabismus Surgery

2014 ◽  
Vol 120 (6) ◽  
pp. 1354-1361 ◽  
Author(s):  
Eun Jung Cho ◽  
Seung Zhoo Yoon ◽  
Jang Eun Cho ◽  
Hye Won Lee
Keyword(s):  
Intravenous Administration ◽  
Controlled Trial ◽  
Pediatric Anesthesia ◽  
Strabismus Surgery ◽  
Secondary Outcome ◽  
Sevoflurane Anesthesia ◽  
Emergence Agitation ◽  
Emergence Time ◽  
Double Blind ◽  
To Receive

Abstract Background: Midazolam has been widely studied for preventing emergence agitation. The authors previously reported that in children with sevoflurane anesthesia, intravenous administration of midazolam (0.05 mg/kg) before the end of surgery reduced the incidence of emergence agitation but prolonged the emergence time. This study was designed to test the hypothesis that a lower midazolam dose could suppress emergence agitation with minimal disturbance of the emergence time in children with sevoflurane anesthesia. Methods: In this randomized, double-blind, placebo-controlled trial, 90 children (1 to 13 yr of age) having strabismus surgery were randomized to 1:1:1 to receive 0.03 mg/kg of midazolam, 0.05 mg/kg of midazolam, or saline just before the end of surgery. The primary outcome, the incidence of emergence agitation, was evaluated by using the pediatric anesthesia emergence delirium scale and the four-point agitation scale. The secondary outcome was time to emergence, defined as the time from sevoflurane discontinuation to the time to extubation. Results: The incidence of emergence agitation was lower in patients given 0.03 mg/kg of midazolam (5 of 30, 16.7%) and patients given 0.05 mg/kg of midazolam (5 of 30, 16.7%) compared with that in patients given saline (13/of 30, 43.3%; P = 0.036 each). The emergence time was longer in patients given 0.05 mg/kg of midazolam (17.1 ± 3.4 min, mean ± SD) compared with that in patients given 0.03 mg/kg of midazolam (14.1 ± 3.6 min; P = 0.0009) or saline (12.8 ± 4.1 min; P = 0.0003). Conclusion: Intravenous administration of 0.03 mg/kg of midazolam just before the end of surgery reduces emergence agitation without delaying the emergence time in children having strabismus surgery with sevoflurane anesthesia. (Anesthesiology 2014; 120:1354-61)

Effect of single-dose dexmedetomidine on emergence agitation and recovery profiles after sevoflurane anesthesia in pediatric ambulatory surgery

2010 ◽  
Vol 24 (5) ◽  
pp. 675-682 ◽  
Author(s):  
Masami Sato ◽  
Gotaro Shirakami ◽  
Misako Tazuke-Nishimura ◽  
Shogo Matsuura ◽  
Keiji Tanimoto ◽  
...  
Keyword(s):  
Single Dose ◽  
Ambulatory Surgery ◽  
Sevoflurane Anesthesia ◽  
Emergence Agitation

scholarly journals A Single Dose of Propofol at the End of Surgery for the Prevention of Emergence Agitation in Children Undergoing Strabismus Surgery during Sevoflurane Anesthesia

2007 ◽  
Vol 107 (5) ◽  
pp. 733-738 ◽  
Author(s):  
Marie T. Aouad ◽  
Vanda G. Yazbeck-Karam ◽  
Viviane G. Nasr ◽  
Mohamad F. El-Khatib ◽  
Ghassan E. Kanazi ◽  
...  
Keyword(s):  
Single Dose ◽  
Pediatric Anesthesia ◽  
Saline Group ◽  
Strabismus Surgery ◽  
Postanesthesia Care Unit ◽  
Double Blind Study ◽  
Healthy Children ◽  
Emergence Agitation ◽  
Double Blind ◽  
Emergence Delirium

Background Emergence agitation in children after sevoflurane is common. Different drugs have been used to decrease its occurrence with variable efficacy. The authors compared the incidence and severity of emergence agitation in children who received a single dose of propofol at the end of strabismus surgery versus children who received saline. Methods In this prospective, randomized, double-blind study, the authors enrolled 80 healthy children aged 2-6 yr. The children were randomly allocated to the propofol group (n = 41), which received 1 mg/kg propofol at the end of surgery, or to the saline group (n = 39), which received saline. Results The mean scores on the Pediatric Anesthesia Emergence Delirium scale were significantly lower in the propofol group compared with the saline group (8.6 +/- 3.9 vs. 11.5 +/- 4.5; P = 0.004). Also, the incidence of agitation was significantly lower in the propofol group compared with the saline group (19.5% vs. 47.2%; P = 0.01). A threshold score greater than 10 on the Pediatric Anesthesia Emergence Delirium scale was the best discriminator between presence and absence of emergence agitation. Times to removal of the laryngeal mask airway (10.6 +/- 1.5 vs. 9.4 +/- 1.9 min; P = 0.004) and emergence times (23.4 +/- 5.7 vs. 19.7 +/- 5 min; P = 0.004) were significantly longer in the propofol group. However, discharge times were similar between the two groups (propofol: 34.1 +/- 8.4 min; saline: 34.9 +/- 8.6 min). More parents in the propofol group were satisfied. Conclusions In children undergoing strabismus surgery, 1 mg/kg propofol at the end of surgery after discontinuation of sevoflurane decreases the incidence of agitation and improves parents' satisfaction without delaying discharge from the postanesthesia care unit.

scholarly journals Effects of propofol and nalbuphine on emergence agitation after sevoflurane anesthesia in children for strabismus surgery

2008 ◽  
Vol 55 (5) ◽  
pp. 575 ◽  
Author(s):  
Hyun-Jung Kim ◽  
Hee-Soo Kim ◽  
Seong-Deok Kim ◽  
Chong-Sung Kim ◽  
Jin-Tae Kim ◽  
...  
Keyword(s):  
Strabismus Surgery ◽  
Sevoflurane Anesthesia ◽  
Emergence Agitation

scholarly journals Effect of peribulbar block on emergence agitation in children undergoing strabismus surgery under desflurane anaesthesia

2018 ◽  
Vol 24 (5) ◽  
pp. 140-144 ◽  
Author(s):  
Jeetinder Kaur Makkar ◽  
Aswini Kuberan ◽  
Preet Mohinder Singh ◽  
Arun Magadi Gopinath ◽  
Kajal Jain ◽  
...  
Keyword(s):  
Strabismus Surgery ◽  
Emergence Agitation ◽  
Peribulbar Block ◽  
Desflurane Anaesthesia
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