scholarly journals 336. Adeno-Associated Viral-Mediated Gene Delivery of Thymosin-beta4 Enhance Heart Function and Improve Survival in TO2 Hamster Heart Failure Model

2008 ◽  
Vol 16 ◽  
pp. S126
2005 ◽  
Vol 11 (9) ◽  
pp. S271
Author(s):  
Eiji Yahiro ◽  
Hidenori Urata ◽  
Yukiko Inoue ◽  
Satomi Abe ◽  
Naoki Hase ◽  
...  

2014 ◽  
Vol 30 (10) ◽  
pp. S126
Author(s):  
S. Salimian ◽  
B. Thibault ◽  
V. Finnerty ◽  
J. Grégoire ◽  
F. Harel

1991 ◽  
Vol 17 (2) ◽  
pp. A133 ◽  
Author(s):  
Karil Bellah ◽  
Thomas Raya ◽  
Sheldon Litwin ◽  
Steven Goldman ◽  
Joel Karliner

Author(s):  
Peter W. Walsh ◽  
Craig S. McLachlan ◽  
Leigh Ladd ◽  
Arie Blitz ◽  
R. Mark Gillies ◽  
...  

Numerous large animal models of chronic cardiac ischemia have been developed to explore either pathological mechanisms and or device interventions in developed heart failure models. Traditionally chronic heart failure in large animal models such as sheep or pigs has been induced by either coronary ligation with or without reperfusion. Coronary ligation is often attempted in the open chest surgical model or more recently in the closed chest animal via angiography [1]. Both techniques can be challenging and also induce high mortality with the risk of myocardial stunning and resultant shock and or lethal arrhythmias. There is also difficulty in developing stable heart failure across cases where infarct sizes can be variable. One strategy to over come this variability has been via rapid ventricular pacing, however inducing heart failure does not induce sustained heart failure in many cases if the pacing is switched off, and additionally pacing does not induce some of the underlying pathology seen in the development of heart failure [1].


2011 ◽  
Vol 17 (8) ◽  
pp. S80 ◽  
Author(s):  
Shelby D. Reed ◽  
Yanhong Li ◽  
Stephen J. Ellis ◽  
David J. Whellan ◽  
Kevin A. Schulman ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document