Collagenase Injection as Nonsurgical Treatment of Dupuytren's Disease: 8-Year Follow-Up

2011 ◽  
Vol 2011 ◽  
pp. 103-104
Author(s):  
D.J. Smith,
Keyword(s):  
Nonsurgical Treatment ◽  
Dupuytren’S Disease ◽  
Dupuytren's Disease ◽  
Collagenase Injection

Collagenase Injection as Nonsurgical Treatment of Dupuytren's Disease: 8-Year Follow-Up

2010 ◽  
Vol 35 (4) ◽  
pp. 534-539.e1 ◽  
Author(s):  
Andrew J. Watt ◽  
Catherine M. Curtin ◽  
Vincent R. Hentz
Keyword(s):  
Nonsurgical Treatment ◽  
Dupuytren’S Disease ◽  
Dupuytren's Disease ◽  
Collagenase Injection

A Comparison of the Direct Outcomes of Percutaneous Needle Fasciotomy and Limited Fasciectomy for Dupuytren’s Disease: A 6-Week Follow-Up Study

2006 ◽  
Vol 31 (5) ◽  
pp. 717-725 ◽  
Author(s):  
Annet L. van Rijssen ◽  
Feike S.J. Gerbrandy ◽  
Hein Ter Linden ◽  
Helen Klip ◽  
Paul M.N. Werker
Keyword(s):  
Dupuytren’S Disease ◽  
Dupuytren's Disease ◽  
Follow Up Study ◽  
Limited Fasciectomy

Dupuytren’s disease

2011 ◽  
Author(s):  
Peter Burge
Keyword(s):  
Surgical Treatment ◽  
Steroid Injection ◽  
Treatment Options ◽  
Genetic Component ◽  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Collagenase Injection ◽  
Operative Complications ◽  
Non Surgical Treatment

♦ Dupuytren’s disease is characterised by contracture of a finger resulting from thickening and shortening of the palmar fascia♦ A genetic component to the aetiology is apparent, smoking, alcohol and diabetes can increase the risk♦ The pathogenesis of Dupuytren’s disease remains elusive♦ Non-surgical treatment options include splintage, steroid injection and collagenase injection♦ Surgery cannot cure the disease but can straighten bent digits and minimize recurrence♦ Operative methods can be considered with regards to incision, management of the diseased fascia and closure techniques♦ Operative complications include injury of digital nerves and arteries

The influence of skin tears following collagenase treatment of Dupuytren’s disease on treatment outcomes

2020 ◽  
pp. 175319342094132
Author(s):  
Robert Phan ◽  
Warren M. Rozen ◽  
Giselle Dela Cruz ◽  
Vicky Tobin ◽  
David J. Hunter-Smith
Keyword(s):  
Patient Reported Outcomes ◽  
Dupuytren’S Disease ◽  
Extension Deficit ◽  
Level Of Evidence ◽  
Dupuytren's Disease ◽  
Finger Extension ◽  
Patient Reported ◽  
Collagenase Injection ◽  
Skin Tears ◽  
Pre Treatment

This study investigated influence of skin tears on patient-reported outcomes of injection of collagenase clostridium histolyticum for Dupuytren’s disease and association between extension deficit of digits before injection and skin tear after the injection. From 2016 to 2018, 391 Dupuytren’s cords were treated in 184 patients in a prospective cohort study and the patients were evaluated before injection and six months after injection. Skin tears occurred in 50% of these patients. We found no significant differences in the patient-reported outcomes between patients with or without skin tears. A higher extension deficit before treatment was associated with significantly increased frequency of skin tears. We conclude that the incidence of skin tears after injection does not affect patient reported outcomes six months after collagenase injection, but the incidence of skin tears is significantly associated with the severity of pre-treatment finger extension deficits. Level of evidence: II

Recurrent Dupuytren’s disease after fasciectomy and collagenase injection are histologically indistinguishable

2020 ◽  
Vol 45 (5) ◽  
pp. 508-512
Author(s):  
Rafael Sanjuan-Cervero ◽  
Francisco J. Carrera-Hueso ◽  
Manuel Vaquero-Perez ◽  
Daniel Montaner-Alonso
Keyword(s):  
Cohort Study ◽  
Prospective Cohort ◽  
Previous Treatment ◽  
Disease Recurrence ◽  
Dupuytren’S Disease ◽  
Collagenase Clostridium Histolyticum ◽  
Dupuytren's Disease ◽  
Clostridium Histolyticum ◽  
Collagenase Injection ◽  
Previously Treated

The aim of this study was to determine whether recurrent Dupuytren’s disease after collagenase Clostridium histolyticum treatment differs histologically from recurrence in those treated with fasciectomy. We carried out a prospective cohort study of patients with Dupuytren’s disease who underwent fasciectomy to treat disease recurrence after previous treatment with collagenase Clostridium histolyticum or fasciectomy. The pathologists and statistician were blinded to the previous treatment. Longitudinal biopsy sections were stained with haematoxylin-eosin and the nodular zones were examined. Fifteen patients were studied: nine previously treated with collagenase Clostridium histolyticum and six previously treated with fasciectomy. There were no histological differences between the samples from the two groups of patients. Dupuytren’s disease recurrences after fasciectomy and collagenase Clostridium histolyticum are histologically indistinguishable.

Recurrence after Surgery for Dupuytren’s Disease: A Randomized Trial of Two Skin Incisions

2005 ◽  
Vol 30 (6) ◽  
pp. 563-566 ◽  
Author(s):  
N. D. CITRON ◽  
V. NUNEZ
Keyword(s):  
Randomized Trial ◽  
Recurrence Rate ◽  
Statistical Difference ◽  
Skin Incision ◽  
Dupuytren’S Disease ◽  
Dupuytren's Disease ◽  
Longitudinal Incision

We studied the influence of the type of skin incision on the recurrence rate following fasciectomy for Dupuytren’s disease. Patients were randomized to a longitudinal incision closed with Z-plasties or a modified Bruner incision closed by Y–V plasties. Follow-up was for at least 2 years or until a recurrence was noted. We found no statistical difference in recurrence rate between patients having these two skin incisions and closures.

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