277 THE INHIBITORY ROLE OF MELATONIN ON ISOLATED RAT URINARY BLADDER CONTRACTION: THE NOVEL PATHWAY FOR THE PHARMACOLOGICAL MANAGEMENT OF NOCTURIA

2010 ◽  
Vol 9 (2) ◽  
pp. 114
Author(s):  
T.H. Kim ◽  
I.H. Chang ◽  
M.S. Ha ◽  
Y.W. Kwon ◽  
M.Y. Lee ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
The Novel ◽  
Pharmacological Management ◽  
Rat Urinary Bladder ◽  
Inhibitory Role ◽  
Bladder Contraction ◽  
Isolated Rat

scholarly journals A Novel Pathway Underlying the Inhibitory Effects of Melatonin on Isolated Rat Urinary Bladder Contraction

2012 ◽  
Vol 16 (1) ◽  
pp. 37 ◽  
Author(s):  
June Hyun Han ◽  
In Ho Chang ◽  
Soon Chul Myung ◽  
Moo Yeol Lee ◽  
Won Yong Kim ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Inhibitory Effects ◽  
Rat Urinary Bladder ◽  
Bladder Contraction ◽  
Isolated Rat

THE ROLE OF INTERLEUKIN-6 ON THE CONTRACTILE RESPONSES OF RAT URINARY BLADDER

2006 ◽  
Vol 5 (2) ◽  
pp. 79
Author(s):  
S.C. Myung ◽  
M.Y. Lee ◽  
M.K. Lee ◽  
S.H. Ahn ◽  
T.H. Kim ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Interleukin 6 ◽  
Rat Urinary Bladder ◽  
Contractile Responses

scholarly journals Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle

2003 ◽  
Vol 138 (5) ◽  
pp. 757-766 ◽  
Author(s):  
Alexandra Wibberley ◽  
Zunxuan Chen ◽  
Erding Hu ◽  
J Paul Hieble ◽  
Timothy D Westfall
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Functional Role ◽  
Rho Kinase ◽  
Bladder Smooth Muscle ◽  
Rat Urinary Bladder ◽  
Urinary Bladder Smooth Muscle

Effect of DHLA on response of isolated rat urinary bladder to repetitive field stimulation

2003 ◽  
pp. 129-135 ◽  
Author(s):  
Robert M Levin ◽  
Abby Borow ◽  
Sheila S Levin ◽  
Niels Haugaard
Keyword(s):  
Urinary Bladder ◽  
Field Stimulation ◽  
Rat Urinary Bladder ◽  
Isolated Rat

Role of endothelin ETA and ETB receptors in the guinea-pig urinary bladder contraction

2003 ◽  
Vol 470 (1-2) ◽  
pp. 99-102 ◽  
Author(s):  
Akira Yoshida ◽  
Yasuko Sakurai-Yamashita ◽  
Kimihiro Yamashita ◽  
Nobuyuki Tanaka ◽  
Kohtaro Taniyama
Keyword(s):  
Urinary Bladder ◽  
Guinea Pig ◽  
Bladder Contraction

scholarly journals A possible role of the cholinergic and purinergic receptor interaction in the regulation of the rat urinary bladder function

2012 ◽  
Vol 32 (6) ◽  
pp. 421-431 ◽  
Author(s):  
Ágnes Jenes ◽  
Ferenc Ruzsnavszky ◽  
Andrea Telek ◽  
Gyula P. Szigeti ◽  
László Csernoch
Keyword(s):  
Urinary Bladder ◽  
Purinergic Receptor ◽  
Bladder Function ◽  
Receptor Interaction ◽  
Rat Urinary Bladder

The role of cholinesterases in rat urinary bladder contractility

2003 ◽  
Vol 31 (3) ◽  
pp. 223-226 ◽  
Author(s):  
Tsutomu Nakahara ◽  
Yuko Kubota ◽  
Kenji Sakamoto ◽  
Kunio Ishii
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder

scholarly journals Role of p75NTR in female rat urinary bladder with cyclophosphamide-induced cystitis

2008 ◽  
Vol 295 (6) ◽  
pp. F1778-F1789 ◽  
Author(s):  
Mary Beth Klinger ◽  
Margaret A. Vizzard
Keyword(s):  
Urinary Bladder ◽  
Intravesical Instillation ◽  
Bladder Function ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Female Rat ◽  
Rat Urinary Bladder ◽  
Micturition Reflex ◽  
Reflex Pathways

Previous studies demonstrated changes in urinary bladder neurotrophin content and upregulation of neurotrophin receptors, TrkA and the p75 neurotrophin receptor (p75NTR), in micturition reflex pathways after cyclophosphamide (CYP)-induced cystitis. p75NTR can bind nerve growth factor (NGF) and modulate NGF-TrkA binding and signaling. We examined p75NTR expression and the role of p75NTR in the micturition reflex in control and CYP-treated rats. p75NTR Immunoreactivity was present throughout the urinary bladder. CYP-induced cystitis (4 h, 48 h, chronic) increased ( P ≤ 0.05) p75NTR expression in whole urinary bladder as shown by Western blotting. The role of p75NTR in bladder function in control and CYP-treated rats was determined using conscious cystometry and immunoneutralization or PD90780, a compound known to specifically block NGF binding to p75NTR. An anti-p75NTR monoclonal antibody or PD90780 was infused intravesically and cystometric parameters were evaluated. Both methods of p75NTR blockade significantly ( P ≤ 0.05) decreased the intercontraction interval and void volume in control and CYP-treated rats. Intravesical infusion of PD90780 also significantly ( P ≤ 0.001) increased intravesical pressure and increased the number of nonvoiding contractions during the filling phase. Control intravesical infusions of isotype-matched IgG and vehicle were without effect. Intravesical instillation of PD90780 significantly ( P ≤ 0.01) reduced the volume threshold to elicit a micturition contraction in control rats (no inflammation) and CYP-treated in a closed urinary bladder system. These studies demonstrate 1) ubiquitous p75NTR expression in urinary bladder and increased expression with CYP-induced cystitis and 2) p75NTR blockade at the level of the urinary bladder produces bladder hyperreflexia in control and CYP-treated rats. The overall activity of the urinary bladder reflects the balance of NGF-p75NTR and NGF-TrkA signaling.

Sign in / Sign up

Export Citation Format

Share Document