S41 EVALUATION OF SURGICAL MARGIN STATUS IN PATIENTS UNDERGOING ROBOTIC-ASSISTED RADICAL PROSTATECTOMY FOR LOW, INTERMEDIATE, AND HIGH-RISK PROSTATE CANCER. AN ANALYSIS OF 3500 CONSECUTIVE CASES

2012 ◽  
Vol 11 (4) ◽  
pp. 141-142
Author(s):  
A.P. Labanaris ◽  
S. Poth ◽  
V. Zugor ◽  
A. Schuette ◽  
C. Wagner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Surgical Margin ◽  
Margin Status ◽  
Robotic Assisted ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer ◽  
Robotic Assisted Radical Prostatectomy

scholarly journals Oncologic Outcome of Radical Prostatectomy as Monotherapy for Men with High-risk Prostate Cancer

2015 ◽  
Vol 9 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Junya Furukawa ◽  
Hideaki Miyake ◽  
Taka-aki Inoue ◽  
Takayoshi Ogawa ◽  
Hirokazu Tanaka ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Seminal Vesicle ◽  
Specific Antigen ◽  
Surgical Margin ◽  
Capsular Invasion ◽  
Seminal Vesicle Invasion ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

Background: The objective of this study was to review our experience with radical prostatectomy (RP) as monotherapy for men with high-risk prostate cancer (PCa). Patients and Methods: This study included 382 consecutive patients who were diagnosed with high-risk PCa according to the D'Amico definition and subsequently underwent RP without neoadjuvant therapy. Biochemical recurrence (BR) was defined as a serum prostate-specific antigen (PSA) level ≥ 0.2 ng/ml on two consecutive measurements, and none of the patients received any adjuvant therapies until their serum PSA levels reached ≥ 0.4 ng/ml. Results: The median preoperative serum PSA level in these 382 patients was 15.9 ng/ml. Pathological stages ≥ pT2c and Gleason scores ≥ 8 were observed in 288 and 194 patients, respectively. During the observation period (median, 48.0 months), BR occurred in 134 patients, and the 5-year BR-free survival rate was 60.1%; however, no patient died of cancer progression. Multivariate analysis identified capsular invasion, seminal vesicle invasion, and surgical margin status as independent predictors of BR. Conclusions: Comparatively favorable cancer control could be achieved using RP as monotherapy for men with high-risk PCa; however, RP alone may be insufficient for patients with capsular invasion, seminal vesicle invasion, and/or surgical margin positivity.

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