Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs

2000 ◽  
Vol 32 (7) ◽  
pp. 583-594 ◽  
Author(s):  
T. Brzozowski ◽  
P.Ch. Konturek ◽  
S.J. Konturek ◽  
Z. Sliwowski ◽  
D. Drozdowicz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Ulcer Healing ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing

scholarly journals Nitric Oxide Regulates Immune Cell Bioenergetic: A Mechanism to Understand Immunomodulatory Functions of Nitric Oxide-Releasing Anti-Inflammatory Drugs

2004 ◽  
Vol 173 (2) ◽  
pp. 874-882 ◽  
Author(s):  
Stefano Fiorucci ◽  
Andrea Mencarelli ◽  
Eleonora Distrutti ◽  
Monia Baldoni ◽  
Piero del Soldato ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Immune Cell ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing

scholarly journals The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-17 ◽  
Author(s):  
Gianluca Farrugia ◽  
Rena Balzan
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Sulfide ◽  
Cancer Prevention ◽  
Mammalian Cell ◽  
Yeast Cells ◽  
Mammalian Cell Lines ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing

Nonsteroidal anti-inflammatory drugs (NSAIDs) have long been used to treat pain, fever, and inflammation. However, mounting evidence shows that NSAIDs, such as aspirin, have very promising antineoplastic properties. The chemopreventive, antiproliferative behaviour of NSAIDs has been associated with both their inactivation of cyclooxygenases (COX) and their ability to induce apoptosisviapathways that are largely COX-independent. In this review, the various proapoptotic pathways induced by traditional and novel NSAIDs such as phospho-NSAIDs, hydrogen sulfide-releasing NSAIDs and nitric oxide-releasing NSAIDs in mammalian cell lines are discussed, as well as the proapoptotic effects of NSAIDs on budding yeast which retains the hallmarks of mammalian apoptosis. The significance of these mechanisms in terms of the role of NSAIDs in effective cancer prevention is considered.

scholarly journals NO-NSAIDs. Part 3: Nitric Oxide-Releasing Prodrugs of Non-steroidal Anti-inflammatory Drugs

2012 ◽  
Vol 60 (4) ◽  
pp. 465-481 ◽  
Author(s):  
Namdev Borhade ◽  
Asif Rahimkhan Pathan ◽  
Somnath Halder ◽  
Manoj Karwa ◽  
Mini Dhiman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing

Nitric Oxide-Releasing Non Steroidal Anti-Inflammatory Drugs: A New Generation of Anti-Tumoral Molecules

2003 ◽  
Vol 3 (6) ◽  
pp. 407-426 ◽  
Author(s):  
Christian Lavagna ◽  
Piero Soldato ◽  
Jean-Luc Burgaud ◽  
Patrick Rampal
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing ◽  
New Generation
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