scholarly journals Nitric Oxide Regulates Immune Cell Bioenergetic: A Mechanism to Understand Immunomodulatory Functions of Nitric Oxide-Releasing Anti-Inflammatory Drugs

2004 ◽  
Vol 173 (2) ◽  
pp. 874-882 ◽  
Author(s):  
Stefano Fiorucci ◽  
Andrea Mencarelli ◽  
Eleonora Distrutti ◽  
Monia Baldoni ◽  
Piero del Soldato ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Immune Cell ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing

Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs

2000 ◽  
Vol 32 (7) ◽  
pp. 583-594 ◽  
Author(s):  
T. Brzozowski ◽  
P.Ch. Konturek ◽  
S.J. Konturek ◽  
Z. Sliwowski ◽  
D. Drozdowicz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Ulcer Healing ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing

scholarly journals The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-17 ◽  
Author(s):  
Gianluca Farrugia ◽  
Rena Balzan
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Sulfide ◽  
Cancer Prevention ◽  
Mammalian Cell ◽  
Yeast Cells ◽  
Mammalian Cell Lines ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing

Nonsteroidal anti-inflammatory drugs (NSAIDs) have long been used to treat pain, fever, and inflammation. However, mounting evidence shows that NSAIDs, such as aspirin, have very promising antineoplastic properties. The chemopreventive, antiproliferative behaviour of NSAIDs has been associated with both their inactivation of cyclooxygenases (COX) and their ability to induce apoptosisviapathways that are largely COX-independent. In this review, the various proapoptotic pathways induced by traditional and novel NSAIDs such as phospho-NSAIDs, hydrogen sulfide-releasing NSAIDs and nitric oxide-releasing NSAIDs in mammalian cell lines are discussed, as well as the proapoptotic effects of NSAIDs on budding yeast which retains the hallmarks of mammalian apoptosis. The significance of these mechanisms in terms of the role of NSAIDs in effective cancer prevention is considered.

Vascular Inflammation in Hypertension: Targeting Lipid Mediators Unbalance and Nitrosative Stress

2019 ◽  
Vol 16 ◽  
Author(s):  
Alexandre Santos Bruno ◽  
Patricia das Dores Lopes ◽  
Karla Caroline Marques de Oliveira ◽  
Anizia Karoline de Oliveira ◽  
Stefany Bruno de Assis Cau
Keyword(s):  
Nitric Oxide ◽  
Nitrosative Stress ◽  
Immune Cell ◽  
Vascular Inflammation ◽  
Organ Damage ◽  
Lipid Mediators ◽  
Hypertension Treatment ◽  
New Concepts ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing

: Arterial hypertension is a worldwide public health threat. High blood pressure (BP) is commonly associated with endothelial dysfunction, nitric oxide synthases (NOS) unbalance and high peripheral vascular resistance. In addition to those, inflammation has also been designated as one of the major components of BP increase and organ damage in hypertension. This minireview discusses vascular inflammatory triggers of high BP and aims to fill the existing gaps of anti-inflammatory therapy of hypertension. Among the reasons discussed, enhanced prostaglandins rather than resolvins lipid mediators, immune cell infiltration and oxidative/nitrosative stress are pivotal players of BP increase within the inflammatory hypothesis. To address these inflammatory targets, this review also proposes new concepts in hypertension treatment with non-steroidal anti-inflammatory drugs (NSAIDs), nitric oxide-releasing NSAIDs (NO-NSAIDs) and specialized proresolving mediators (SPM). In this context, the failure of NSAIDs in hypertension treatment seems to be associated with the reduction of endogenous NO bioavailability, which is not necessarily an effect of all drug members of this pharmacological class. For this reason, NO-releasing NSAIDs seem to be safer and more specific therapy to treat vascular inflammation in hypertension than regular NSAIDs.

scholarly journals NO-NSAIDs. Part 3: Nitric Oxide-Releasing Prodrugs of Non-steroidal Anti-inflammatory Drugs

2012 ◽  
Vol 60 (4) ◽  
pp. 465-481 ◽  
Author(s):  
Namdev Borhade ◽  
Asif Rahimkhan Pathan ◽  
Somnath Halder ◽  
Manoj Karwa ◽  
Mini Dhiman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing
Sign in / Sign up

Export Citation Format

Share Document