Comparison of Tamsulosin, Nifedipine, and Placebo for Ureteric Colic

Clinical questionDo calcium channel blockers or alpha blockers improve renal stone passage when compared with placebo?Article chosenPickard R, Starr K, MacLennan G, et al. Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial. Lancet 2015;386(9991):25-31, doi: 10.1016/S0140-6736(15)60933-3.

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Medical Expulsive Therapy

10.2310/uro.11010 ◽

2019 ◽

Author(s):

Mark Silva ◽

Nina Mikkilineni ◽

Ojas Shah

Keyword(s):

Calcium Channel ◽

Calcium Channel Blockers ◽

Phosphodiesterase Inhibitors ◽

Ureteral Stones ◽

Channel Blockers ◽

Medical Expulsive Therapy ◽

Randomized Controlled ◽

Meta Analyses ◽

Pharmaceutical Agents ◽

Stone Passage

Medical expulsive therapy (MET) for ureteral stones involves the administration of pharmaceutical agents to facilitate passage of stones by ideally increasing the rate of passage and reducing time for expulsion. Several medications have been studied for this use. The most commonly studied off-label medications include α1-antagonists and calcium channel blockers. This article reviews the data available for the use of MET and controversies in the use of medications to aid stone passage based on more recent randomized controlled trials and meta-analyses. Based on the latest guidelines, α-blockers have been the most studied medication type and may have some benefit in the passage of distal ureteral stones greater than 4 mm in size. This review contains 2 figures and 34 references. Keywords: α1-antagonists, α-blockers, calcium channel blockers, medical expulsion therapy, phosphodiesterase inhibitors, ureteral stones

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D108 Is there a potentiation effect between alpha blockers and calcium channel blockers in the treatment of essential hypertension

American Journal of Hypertension ◽

10.1016/s0895-7061(97)89143-1 ◽

1997 ◽

Vol 10 (4) ◽

pp. 133A

Author(s):

S NALBANTQIL

Keyword(s):

Essential Hypertension ◽

Calcium Channel ◽

Calcium Channel Blockers ◽

Channel Blockers ◽

Alpha Blockers ◽

Potentiation Effect

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Medical Expulsive Therapy (MET) in Adults With Ureteric Colic

50 Studies Every Urologist Should Know ◽

10.1093/med/9780190655341.003.0037 ◽

2021 ◽

pp. 209-214

Author(s):

Michael S. Borofsky ◽

Vincent G. Bird

Keyword(s):

Randomized Controlled Trial ◽

Adverse Events ◽

Calcium Channel ◽

Controlled Trial ◽

Negative Trial ◽

Ureteral Stones ◽

Serious Adverse Events ◽

Medical Expulsive Therapy ◽

The Mean ◽

Ureteric Colic

This chapter summarizes the results of the SUSPEND trial, a methodologically rigorous three-armed randomized controlled trial of medical expulsive therapy in the form of the alpha-blocker tamsulosin or the calcium channel blocker nifedipine versus placebo. The mean stone size in all three groups was comparable and three-quarters of the stones were 5 mm or less. It was a “negative trial” that failed to demonstrate a substantial benefit from the widely established practice of treating patients with small ureteral stones with medical expulsive therapy. Serious adverse events were very infrequent.

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ASSESSMENT OF WHOQOL BREF DOMAINS AND ANTIHYPERTENSIVES PRESCRIPTION PATTERN IN HEMODIALYSIS PATIENTS

10.36106/ijsr/2105417 ◽

2021 ◽

pp. 81-85

Author(s):

Peddoju Moulika ◽

Deveraneni Vinay ◽

Raparthi saichandra ◽

Ganta Saidhulu ◽

Pranith Ram

Keyword(s):

Calcium Channel ◽

Calcium Channel Blockers ◽

Beta Blockers ◽

Channel Blockers ◽

Prescribing Pattern ◽

Alpha Blockers ◽

Study Population ◽

Esrd Patients ◽

Physical Health Domain

Background: ESRD is considered as an important cause of mortality worldwide. Patients with CKD on Hemodialysis treatment is very complex requires additional importance in prescribing antihypertensives and also patients on Hemodialysis have effects on functional state and quality of life (QOL). Objectives: The study aimed to assess prescribing pattern of antihypertensives and to demonstrate QOL in different domains of patients with ESRD underdoing hemodialysis. Materials and Methods: Study comprised of 85 patients with ESRD under hemodialysis conducted in multi-speciality hospital between September 2019 to February 2020.The data was collected from the records and by interviewing patients. Results: The mean age of the study population was 54.76±14.32, 72% were males, hypertension is the common cause of ESRD. Calcium channel blockers are the most commonly prescribed drugs followed by alpha blockers, diuretics, beta blockers, vasodilators etc. Comparing the four domains of ESRD patients, environmental domain was the highest with a mean score of 64.56±19.86while the physical health domain was the lowest with a mean score of55.6±12.60. Conclusion: Calcium channel blockers and alpha blockers are most commonly prescribed antihypertensives. The four domains were signicantly and positively interrelated with moderate to strong relationships

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