scholarly journals The use of the haemagglutination-inhibition test in epidemiological influenza-virus studies

1949 ◽  
Vol 47 (4) ◽  
pp. 396-397 ◽  
Author(s):  
Hendrik L. Wolff
Keyword(s):  
Influenza Virus ◽  
Influenza Infection ◽  
Haemagglutination Inhibition ◽  
Inhibition Test ◽  
Haemagglutination Inhibition Test

The importance of the haemagglutination-inhibition test does not need to be stressed. It is a fact that the inhibition titre of a single serum has no constant value, but may vary in repeated estimations. This may be due to the use of different virus or erythrocyte suspensions or to differences in environmental circumstances, such as temperature. Duplicate tests carried out at the same time and with the same materials yield identical results. This makes it necessary to compare a serum obtained during convalescence from the same case. The ratio between the two titres shows whether an influenza infection has taken place or not. Although it is commonly accepted that a titre rising by two twofold dilutions (a fourfold rise) is significant, some workers will accept even a twofold rise (Sartwill & Long, 1948; Rasmussen, Stoles & Smadel, 1948). Such observations have been made on pairs of sera taken from the same indicidual with not more than a 5-week interval between them.

scholarly journals The postnatal acquisition of factors which affect the influenza haemagglutination-inhibition test

1982 ◽  
Vol 89 (2) ◽  
pp. 329-334 ◽  
Author(s):  
P. C. A. Grint ◽  
S. Argent ◽  
R. B. Heath
Keyword(s):  
Influenza Virus ◽  
Surface Antigen ◽  
Complement Fixation ◽  
Haemagglutination Inhibition ◽  
Inhibition Test ◽  
Serum Factors ◽  
Specific Serum ◽  
Haemagglutination Inhibition Test

SUMMARYLevels of maternally transferred antibodies against the surface antigen of the A/Texas/1/77 strain of influenza virus showed the expected decline during infancy when measured by complement fixation (CF). However, this decline was not observed when these antibodies were measured by haemagglutination-inhibition (HI). It has been postulated that this discrepancy is due to the acquisition, in the early days of life, of non-specific serum factors which increase the HI activity of sera. The levels of these factors were determined indirectly by calculating HI: CF ratios and it was shown that the factors are rapidly acquired by children between the fifth and twentieth week of life.

A scheme for the identification of the blood of Australasian marsupials

1969 ◽  
Vol 17 (5) ◽  
pp. 799 ◽  
Author(s):  
JAW Kirsch ◽  
MD Murray
Keyword(s):  
Geographical Distribution ◽  
Haemagglutination Inhibition ◽  
Inhibition Test ◽  
Haemagglutination Inhibition Test ◽  
Blood Sucking ◽  
The Family ◽  
Precipitin Test ◽  
Marsupial Species

A collection of sera from 81 species of Australasian marsupials and 65 antisera to them, prepared in rabbits, chickens, or various species of marsupials, was examined to devise a scheme to identify the blood of marsupials imbibed by blood-sucking insects. The precipitin test was of limited value but established that the blood was marsupial. With the haemagglutination inhibition test, however, it was possible to identify the family, subfamily, genus, and species. Thus a procedure could be devised to identify the donors' blood based principally on serological methods supplemented by data on the geographical distribution of the various marsupial species.

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