Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics

Akihiro Takano; Tetsuya Suhara; Yoko Ikoma; Fumihiko Yasuno; Jun Maeda; Tetsuya Ichimiya; Yasuhiko Sudo; Makoto Inoue; Yoshiro Okubo

doi:10.1017/s1461145703003912

Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics

The International Journal of Neuropsychopharmacology ◽

10.1017/s1461145703003912 ◽

2004 ◽

Vol 7 (1) ◽

pp. 19-26 ◽

Cited By ~ 36

Author(s):

Akihiro Takano ◽

Tetsuya Suhara ◽

Yoko Ikoma ◽

Fumihiko Yasuno ◽

Jun Maeda ◽

...

Keyword(s):

Human Brain ◽

Time Course ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Occupancy ◽

Dopamine D2 ◽

Dopamine D2 Receptor Occupancy ◽

Plasma Pharmacokinetics

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Estimation of time course of dopamine D2 receptor occupancy from plasma pharmacokinetics of antipsychotics

International Congress Series ◽

10.1016/j.ics.2003.12.060 ◽

2004 ◽

Vol 1264 ◽

pp. 173-176 ◽

Cited By ~ 1

Author(s):

Akihiro Takano ◽

Tetsuya Suhara ◽

Yoko Ikoma ◽

Fumihiko Yasuno ◽

Jun Maeda ◽

...

Keyword(s):

Time Course ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Occupancy ◽

Dopamine D2 ◽

Dopamine D2 Receptor Occupancy ◽

Plasma Pharmacokinetics ◽

Estimation Of Time

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On the simulation of the time-course of dopamine D2 receptor occupancy from the pharmacokinetics of antipsychotics

The International Journal of Neuropsychopharmacology ◽

10.1017/s1461145704004778 ◽

2005 ◽

Vol 8 (1) ◽

pp. 137-139 ◽

Cited By ~ 1

Author(s):

Adriano B. L. Tort ◽

Diogo O. Souza ◽

Diogo R. Lara

Keyword(s):

Time Course ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Occupancy ◽

Dopamine D2 ◽

Dopamine D2 Receptor Occupancy

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Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2005.06.011 ◽

2006 ◽

Vol 30 (1) ◽

pp. 75-81 ◽

Cited By ~ 15

Author(s):

Akihiro Takano ◽

Tetsuya Suhara ◽

Ichiro Kusumi ◽

Yoshito Takahashi ◽

Yoshiyuki Asai ◽

...

Keyword(s):

Time Course ◽

Dopamine D2 Receptor ◽

Plasma Concentrations ◽

D2 Receptor ◽

Receptor Occupancy ◽

High Plasma ◽

Dopamine D2 ◽

Dopamine D2 Receptor Occupancy

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P.3.05 In vivo123Iodobenzamide SPECT quantification of striatal dopamine D2 receptor occupancy of risperidone depot in patients with psychosis

European Neuropsychopharmacology ◽

10.1016/s0924-977x(04)90060-0 ◽

2004 ◽

Vol 14 ◽

pp. S49-S50

Author(s):

G. Wiesegger ◽

N. Klein ◽

T. Attarbaschi ◽

S. Asenbaum ◽

D. Winkler ◽

...

Keyword(s):

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Occupancy ◽

Striatal Dopamine ◽

Dopamine D2 ◽

Dopamine D2 Receptor Occupancy

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Dopamine D2 Receptor Occupancy as a Predictor of Catalepsy in Rats: A Pharmacokinetic-Pharmacodynamic Modeling Approach

Pharmaceutical Research ◽

10.1007/s11095-014-1358-7 ◽

2014 ◽

Vol 31 (10) ◽

pp. 2605-2617 ◽

Cited By ~ 8

Author(s):

Martin Johnson ◽

Magdalena Kozielska ◽

Venkatesh Pilla Reddy ◽

An Vermeulen ◽

Hugh A. Barton ◽

...

Keyword(s):

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Occupancy ◽

Pharmacodynamic Modeling ◽

Modeling Approach ◽

Dopamine D2 ◽

Dopamine D2 Receptor Occupancy

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Poster #217 PREDICTING DOPAMINE D2 RECEPTOR OCCUPANCY FOLLOWING ANTIPSYCHOTIC DOSE REDUCTION: A PILOTPETSTUDY

Schizophrenia Research ◽

10.1016/s0920-9964(12)71049-6 ◽

2012 ◽

Vol 136 ◽

pp. S359

Author(s):

Hiroyuki Uchida ◽

Robert R. Bies ◽

Takefumi Suzuki ◽

Ariel Graff-Guerrero ◽

Bruce G. Pollock ◽

...

Keyword(s):

Dose Reduction ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Occupancy ◽

Dopamine D2 ◽

Dopamine D2 Receptor Occupancy

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Relationships between dopamine-D2 receptor occupancy and dopa decarboxylase activity. A pet-study in neuroleptic treated patients with patient with schizophrenia

Schizophrenia Research ◽

10.1016/s0920-9964(97)88733-6 ◽

1998 ◽

Vol 29 (1-2) ◽

pp. 167

Author(s):

F.-A. Wiesel ◽

M. Bela ◽

O.E. Gefvert ◽

G. Hagberg ◽

B. Långström ◽

...

Keyword(s):

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Occupancy ◽

Dopa Decarboxylase ◽

Decarboxylase Activity ◽

Dopamine D2 ◽

Dopamine D2 Receptor Occupancy

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Poster #218 DOPAMINE D2 RECEPTOR OCCUPANCY AND COGNITION IN SCHIZOPHRENIA: ANALYSIS OF THE CATIE DATA

Schizophrenia Research ◽

10.1016/s0920-9964(12)71050-2 ◽

2012 ◽

Vol 136 ◽

pp. S359

Author(s):

Hiroyuki Uchida ◽

Hitoshi Sakurai ◽

Robert R. Bies ◽

Scott Stroup ◽

Richard S.E. Keefe ◽

...

Keyword(s):

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Occupancy ◽

Dopamine D2 ◽

Dopamine D2 Receptor Occupancy

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Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1365 ◽

2019 ◽

Vol 59 (5) ◽

pp. 731-747 ◽

Cited By ~ 2

Author(s):

Yin Cheong Wong ◽

Maddalena Centanni ◽

Elizabeth C. M. Lange

Keyword(s):

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Occupancy ◽

Modeling Approach ◽

Dopamine D2 ◽

Dopamine D2 Receptor Occupancy ◽

Physiologically Based

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Subjective Experience and Striatal Dopamine D2 Receptor Occupancy in Patients With Schizophrenia Stabilized by Olanzapine or Risperidone

American Journal of Psychiatry ◽

10.1176/appi.ajp.157.6.1019 ◽

2000 ◽

Vol 157 (6) ◽

pp. 1019-1020 ◽

Cited By ~ 86

Author(s):

L. de Haan

Keyword(s):

Subjective Experience ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Occupancy ◽

Striatal Dopamine ◽

Dopamine D2 ◽

Dopamine D2 Receptor Occupancy

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