Dispersion Forces and the Molecular Origin of Internal Friction in Protein

Biochemistry ◽  
2016 ◽  
Vol 55 (33) ◽  
pp. 4595-4602 ◽  
Author(s):  
Pulikallu Sashi ◽  
Dasari Ramakrishna ◽  
Abani K. Bhuyan
Keyword(s):  
Internal Friction ◽  
Dispersion Forces ◽  
Molecular Origin

scholarly journals Non-native Interactions Explain the Folding Rate Differences in α-Spectrin Domains and the Origin of Internal Friction Effects

2017 ◽  
Author(s):  
Fernando Bruno da Silva ◽  
Vinícius G. Contessoto ◽  
Vinícius M. de Oliveira ◽  
Jane Clarke ◽  
Vitor B. P. Leite
Keyword(s):  
Experimental Data ◽  
Protein Folding ◽  
Internal Friction ◽  
Computational Studies ◽  
Folding Rate ◽  
Folding Rates ◽  
Cooperativity Effect ◽  
Folding Dynamics ◽  
Molecular Origin ◽  
Dynamics Simulations

AbstractRecent experimental and computational studies have shown the influence of internal friction in protein folding dynamics. However, uncertainty remains over its molecular origin. α-spectrin experimental results indicate that R15 domain folds three orders of magnitude faster than its homologous R16 and R17. Such anomalous observations are usually attributed to the influence of internal friction on protein folding rates. To study this phenomenon, we carried out molecular dynamics simulations with structure-based Cα models, in which the folding process of α-spectrin domains was investigated by adding non-native interactions. The simulations take into account the hydrophobic and the electrostatic contributions separately. The folding time results have shown a qualitative agreement with experimental data. We have also investigated mutations in R16 and R17, and the simulation folding time results correlate with the observed experimental ones. We suggest that the origin of the internal friction emerges from a cooperativity effect of these non-native interactions.

Internal friction in a martensitic high-carbon steel

2001 ◽  
Vol 81 (12) ◽  
pp. 2797-2808
Author(s):  
Rustem Bagramov, Daniele Mari, Willy Benoi
Keyword(s):  
Carbon Steel ◽  
Internal Friction ◽  
High Carbon Steel ◽  
High Carbon

A simple system to measure internal friction and creep

1992 ◽  
Vol 2 (9) ◽  
pp. 1779-1786
Author(s):  
A. M. Bastawros ◽  
M. Z. Said
Keyword(s):  
Internal Friction ◽  
Simple System

Internal friction and some other properties of shape memory Fe-Mn-Si based alloys

2003 ◽  
Vol 112 ◽  
pp. 397-400 ◽  
Author(s):  
P. G. Yakovenko ◽  
O. Söderberg ◽  
K. Ullakko ◽  
V. K. Lindroos
Keyword(s):  
Internal Friction ◽  
Shape Memory

LOW TEMPERATURE INTERNAL FRICTION OF COLD WORKED ZIRCONIUM

1971 ◽  
Vol 32 (C2) ◽  
pp. C2-209-C2-213 ◽  
Author(s):  
E. J. SAVINO ◽  
E. A. BISOGNI
Keyword(s):  
Low Temperature ◽  
Internal Friction ◽  
Cold Worked

INTERNAL FRICTION IN RHENIUM

1971 ◽  
Vol 32 (C2) ◽  
pp. C2-179-C2-181
Author(s):  
M. RAADSCHELDERS ◽  
R. DE BATIST
Keyword(s):  
Internal Friction
Sign in / Sign up

Export Citation Format

Share Document